Effect of Neuromodulation of Short-term Plasticity on Information Processing in Hippocampal Interneuron Synapses

Journal of Mathematical Neuroscience
Elham Bayat MokhtariEmily F Stone

Abstract

Neurons in a micro-circuit connected by chemical synapses can have their connectivity affected by the prior activity of the cells. The number of synapses available for releasing neurotransmitter can be decreased by repetitive activation through depletion of readily releasable neurotransmitter (NT), or increased through facilitation, where the probability of release of NT is increased by prior activation. These competing effects can create a complicated and subtle range of time-dependent connectivity. Here we investigate the probabilistic properties of facilitation and depression (FD) for a presynaptic neuron that is receiving a Poisson spike train of input. We use a model of FD that is parameterized with experimental data from a hippocampal basket cell and pyramidal cell connection, for fixed frequency input spikes at frequencies in the range of theta (3-8 Hz) and gamma (20-100 Hz) oscillations. Hence our results will apply to micro-circuits in the hippocampus that are responsible for the interaction of theta and gamma rhythms associated with learning and memory. A control situation is compared with one in which a pharmaceutical neuromodulator (muscarine) is employed. We apply standard information-theoretic measures such as ent...Continue Reading

References

Jan 10, 1997·Science·L F AbbottS B Nelson
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·M V Tsodyks, H Markram
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MarkramM Tsodyks
Jun 6, 1998·Neural Computation·M TsodyksH Markram
Jan 11, 2002·Journal of Neurophysiology·Galit FuhrmannMisha Tsodyks
Jan 29, 2002·Journal of Theoretical Biology·Bo Cartling
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Mar 16, 2002·Nature Neuroscience·Michael LondonIdan Segev
Jun 1, 2004·Nature·Frédéric Pouille, Massimo Scanziani
Jul 13, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Alexander KraskovPeter Grassberger
Oct 16, 2004·Nature·Alain Destexhe, Eve Marder
Oct 16, 2004·Nature·L F Abbott, Wade G Regehr
Nov 21, 2008·Neural Computation·Zhijun YangBruce P Graham
Dec 19, 2008·Journal of Computational Neuroscience·Chuang-Chung J LeeGregory J McRae
Feb 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin LindnerJohn E Lewis
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ziv RotmanVitaly A Klyachko
Mar 27, 2012·Annual Review of Neuroscience·György Buzsáki, Xiao-Jing Wang
Jun 28, 2012·PLoS Computational Biology·Robert RosenbaumBrent Doiron
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Csaba VargaIvan Soltesz
Jul 25, 2013·Frontiers in Neural Circuits·T P VogelsH Sprekeler
Jan 26, 2017·Current Opinion in Neurobiology·Haroon AnwarFarzan Nadim

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Citations

Jan 9, 2019·Journal of Mathematical Neuroscience·Zachary P KilpatrickRobert Rosenbaum

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Software Mentioned

lsqnonlin
Matlab package

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