PMID: 3763961Aug 1, 1986Paper

Effect of neurotensin and neurotensin fragments on gastric acid secretion in man

Regulatory Peptides
J Holst PedersenP Kirkegaard

Abstract

The effect of intravenous infusion of neurotensin (NT) and NT-fragments on pentagastrin stimulated gastric acid secretion was investigated in healthy subjects. Neurotensin was infused in three doses (72, 144 and 288 pmol/kg per h). An N-terminal fragment (NT 1-8), a C-terminal fragment (NT 8-13) and an NT-analogue, substituted at the C-terminal tyrosine residue (Phe11-NT) were infused in two doses (72 and 144 pmol/kg per h). Concentrations of the infused peptides were measured in peripheral venous blood by radioimmunoassay. Plasma levels of NT 1-13, NT 1-8 and Phe11-NT increased in a dose-dependent manner; NT 1-13 to 50 (34-69), 78 (54-113) and 143 (112-242) pmol/l (medians and range) at 72, 144 and 288 pmol/kg per h, NT 1-8 to 405 (340-465) and 1215 (915-1300) pmol/l, and Phe11-NT to 200 (110-245) and 390 (250-410) pmol/l at 72 and 144 pmol/kg per h, respectively. Increases in plasma levels of NT 8-13 could not be detected during the infusion, suggesting that the fragment is rapidly metabolized in man. Neurotensin 1-13 inhibited gastric acid secretion in a dose-dependent manner and the decrease in gastric acid secretion was linearly related to plasma levels of NT 1-13. Neurotensin 1-8 and NT 8-13 inhibited gastric acid secreti...Continue Reading

References

May 10, 1980·Lancet·A M BlackburnJ H Baron
Mar 1, 1982·Regulatory Peptides·B H HirstL Wilson
Nov 1, 1984·Regulatory Peptides·J MiskowiakF Stadil
Jul 1, 1983·Regulatory Peptides·E Theodorsson-Norheim, S Rosell
Oct 1, 1983·Scandinavian Journal of Clinical and Laboratory Investigation·J H PedersenJ Fahrenkrug
Nov 1, 1983·Scandinavian Journal of Gastroenterology·P Skov OlsenJ Christiansen
Jul 1, 1984·The Journal of Clinical Endocrinology and Metabolism·Y C LeeS R Bloom
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Jan 1, 1980·Scandinavian Journal of Gastroenterology·S AnderssonK Folkers
Aug 1, 1980·British Journal of Pharmacology·R QuirionS St-Pierre

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Citations

May 1, 1988·Regulatory Peptides·J Holst PedersenJ J Holst
Sep 1, 1989·Journal of Gastroenterology and Hepatology·A ShulkesK J Hardy
Oct 1, 1987·The Journal of Clinical Investigation·M H MogardJ H Walsh
Aug 12, 2008·Physiology & Behavior·P W J MaljaarsA A M Masclee
Feb 1, 1990·Scandinavian Journal of Gastroenterology·J Holst PedersenN Palmgren
Jan 1, 1990·Scandinavian Journal of Gastroenterology·V E EysseleinH Goebell
Jan 11, 2013·Physiological Reviews·Sascha Kopic, John P Geibel

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