PMID: 2568658Jan 1, 1989Paper

Effect of neurotransmitters on the system that transports Tyr-MIF-1 and the enkephalins across the blood-brain barrier: a dominant role for serotonin

Psychopharmacology
W A Banks, A J Kastin

Abstract

Neurotransmitters and neuropeptides interact in several ways. We studied a new type of interaction: the effect of neurotransmitters on the saturable system that transports Tyr-MIF-1 and the enkephalins out of the central nervous system (CNS). The neurotransmitters were introduced into the lateral ventricle of the brain with radioiodinated peptide, using an established method previously shown to accurately quantify the amount of peptide being transported from the CNS to the blood. Serotonin inhibited transport, histamine stimulated transport, and dopamine, acetylcholine, epinephrine, GABA, kainic acid, cAMP and cGMP were without effect. Cyproheptadine, a serotonin antagonist, stimulated transport. Of several psychotropic agents tested, only tranylcypromine had a statistically significant effect and stimulated transport. Of the serotonin receptor specific agents tested, those with 5HT1 activity most consistently affected transport. We conclude that serotonin, and perhaps histamine, are important modulators of the system that transports Tyr-MIF-1 and the enkephalins out of the CNS.

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Citations

Jan 1, 1994·Neuroscience and Biobehavioral Reviews·G W ReedR D Olson
May 1, 1992·Brain Research. Brain Research Reviews·C NilssonC Owman
Nov 1, 1990·Peptides·G A OlsonA J Kastin
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·S R PlotkinA J Kastin
Oct 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·K L ReicheltW H Reichelt
Oct 31, 1994·Annals of the New York Academy of Sciences·W A Banks, A J Kastin
Mar 1, 1993·Journal of Neurochemistry·J Brownlees, C H Williams
Mar 15, 1996·Experientia·A R Ameen
Mar 22, 1996·Annals of the New York Academy of Sciences·A J KastinW A Banks
Apr 28, 2009·Progress in Neurobiology·Ivona BrasnjevicUNKNOWN European NanoBioPharmaceutics Research Initiative
Mar 26, 2015·Peptides·William A Banks
May 29, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Min ShiJing Zhang
Jan 1, 1995·Neuroradiology·M SumidaF Ikawa
Jan 1, 1995·Scandinavian Journal of Thoracic and Cardiovascular Surgery·J StarkopfJ Samarütel

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