PMID: 2568658Jan 1, 1989Paper

Effect of neurotransmitters on the system that transports Tyr-MIF-1 and the enkephalins across the blood-brain barrier: a dominant role for serotonin

W A Banks, A J Kastin


Neurotransmitters and neuropeptides interact in several ways. We studied a new type of interaction: the effect of neurotransmitters on the saturable system that transports Tyr-MIF-1 and the enkephalins out of the central nervous system (CNS). The neurotransmitters were introduced into the lateral ventricle of the brain with radioiodinated peptide, using an established method previously shown to accurately quantify the amount of peptide being transported from the CNS to the blood. Serotonin inhibited transport, histamine stimulated transport, and dopamine, acetylcholine, epinephrine, GABA, kainic acid, cAMP and cGMP were without effect. Cyproheptadine, a serotonin antagonist, stimulated transport. Of several psychotropic agents tested, only tranylcypromine had a statistically significant effect and stimulated transport. Of the serotonin receptor specific agents tested, those with 5HT1 activity most consistently affected transport. We conclude that serotonin, and perhaps histamine, are important modulators of the system that transports Tyr-MIF-1 and the enkephalins out of the CNS.


Oct 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·T DukaA Herz
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Jan 1, 1987·Journal of Cardiovascular Pharmacology·M Göthert, E Schlicker
Dec 8, 1986·Life Sciences·Z H Galina, A J Kastin
Feb 1, 1988·Biological Psychiatry·P GiralP Simon
Apr 1, 1988·The Journal of Pharmacy and Pharmacology·W A Banks, A J Kastin
Jul 7, 1988·European Journal of Pharmacology·L Pulvirenti, A J Kastin
Sep 14, 1987·Life Sciences·D J GoldsteinH R Keiser
Oct 1, 1987·Alcoholism, Clinical and Experimental Research·K Gill, Z Amit
Jun 1, 1988·Pharmacology, Biochemistry, and Behavior·K M WozniakD L Murphy
Mar 1, 1988·Trends in Pharmacological Sciences·D Hoyer
Sep 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·S J Won, M T Lin
Mar 1, 1988·Pain·Carlo A Porro, Giancarlo Carli
May 1, 1988·The American Journal of the Medical Sciences·W A Banks, A J Kastin
Jan 1, 1988·Journal of Receptor Research·D Hoyer
Sep 14, 1987·Life Sciences·W A Banks, A J Kastin
Jan 1, 1988·Journal of Neural Transmission·D T WongT K Li
Jan 1, 1988·Neurobiology of Aging·W A Banks, A J Kastin
Dec 1, 1987·Brain Research Bulletin·C M BarreraW A Banks
Jan 1, 1987·The Journal of Clinical Endocrinology and Metabolism·B J WallumD Dorsa
Jan 1, 1987·Journal of Neuroscience Research·W A BanksE A Michals
Jan 1, 1985·Psychoneuroendocrinology·W A Banks, A J Kastin
Nov 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·O P VakulinaO S Brusov
Dec 1, 1984·Neuropharmacology·M H Roberts

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Jan 1, 1994·Neuroscience and Biobehavioral Reviews·G W ReedR D Olson
May 1, 1992·Brain Research. Brain Research Reviews·C NilssonC Owman
Nov 1, 1990·Peptides·G A OlsonA J Kastin
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·S R PlotkinA J Kastin
Oct 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·K L ReicheltW H Reichelt
Oct 31, 1994·Annals of the New York Academy of Sciences·W A Banks, A J Kastin
Mar 1, 1993·Journal of Neurochemistry·J Brownlees, C H Williams
Mar 15, 1996·Experientia·A R Ameen
Mar 22, 1996·Annals of the New York Academy of Sciences·A J KastinW A Banks
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Mar 26, 2015·Peptides·William A Banks
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Jan 1, 1995·Neuroradiology·M SumidaF Ikawa
Jan 1, 1995·Scandinavian Journal of Thoracic and Cardiovascular Surgery·J StarkopfJ Samarütel

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