Effect of neutral pH and low-glucose degradation product-containing peritoneal dialysis solution on residual renal function in peritoneal dialysis patients: a meta-analysis

Nephron
Jialin WangWeijie Yuan

Abstract

Glucose degradation products (GDPs) in peritoneal dialysis (PD) solution (PDS) have been shown to inflict damage to the kidney, which is the major organ for advanced glycosylation end product elimination. Hence, this study investigated whether new PDSs with neutral pH and low-GDPs have a beneficial effect on the preservation of residual renal function (RRF) among PD patients. Randomized controlled trials examining the effect of neutral pH and low-GDP PDSs on RRF in PD patients >18 years old compared with conventional PDSs were selected. The modality of PD treatment was continuous ambulatory PD. The primary outcome variable was mean RRF value. Weekly Kt/V, urine volume, peritoneal ultrafiltration, blood pressure and all-cause mortality of PD patients were measured as secondary outcome variables. We identified 6 randomized controlled trials and found that patients using low-GDP PDSs had a much slower rate of RRF loss compared with patients using conventional PDSs [mean difference (MD) = 0.45, 95% confidence intervals (CI) 0.10-0.80, p = 0.01]. In addition, weekly Kt/V was markedly improved in the low-GDP PDS group (MD = 0.13, 95% CI 0.06-0.21, p = 0.0005), and urine volume was increased (MD = 110.34, 95% CI 8.58-212.10, p = 0.03)...Continue Reading

Citations

Jun 21, 2016·Drug Discovery Today·Monika PischetsriederIngrid Weigel
Feb 6, 2017·Seminars in Nephrology·Cheuk Chun Szeto, David W Johnson
Mar 30, 2017·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Karima FarhatFrans J van Ittersum
Dec 10, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Htay HtayUNKNOWN balANZ trial investigators
Oct 21, 2015·The International Journal of Artificial Organs·Bernd RamsauerBernd Stegmayr
Mar 1, 2017·Pleura and Peritoneum·Kunio KawanishiChieko Hamada

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