Effect of NF-κB decoy oligodeoxynucleotide on LPS/high-fat diet-induced atherosclerosis in an animal model

Basic & Clinical Pharmacology & Toxicology
Soo-Jung KimKwan-Kyu Park

Abstract

Atherosclerosis is a chronic inflammatory process occurring in the walls of arteries, in large part due to the accumulation of inflammatory cells. This study was conducted to determine the effect of nuclear factor (NF)-κB decoy oligodeoxynucleotide (ODN) in an atherosclerosis animal model. The mice received i.p. injections of lipopolysaccharide (LPS, 2 mg/kg) three times a week to induce atherosclerotic change, and fed an atherogenic diet for 12 weeks. NF-κB decoy ODN (0.4 mg/kg) was injected into the tail vein. Treatment with NF-κB decoy ODN decreased pro-inflammatory cytokines, tumour necrosis factor (TNF)-α and interleukin (IL)-1β and inflammatory markers, vascular adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1, in the LPS/Fat-induced mice. In addition, the expression of proteins related to fibrosis, transforming growth factor (TGF)-β1 and fibronectin were markedly decreased in the mice treated with NF-κB decoy ODN compared with the LPS/Fat-induced mice without decoy ODN treatment. These data suggest that NF-κB decoy ODN may exert an inhibitory effect on the expression levels of pro-inflammatory cytokines and cell adhesion molecules in atherosclerotic mice.

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Citations

Dec 11, 2013·Clinical & Developmental Immunology·Jing-qin NiYun Zhang
Jul 19, 2011·Journal of the American Chemical Society·Jeane M GovanAlexander Deiters
Jul 23, 2011·Cellular Immunology·John J Haddad, Nisreen E Abdel-Karim
May 31, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Soo-Jung KimKwan-Kyu Park
Jul 24, 2014·Preventive Nutrition and Food Science·Mi Joung KimHo-Kyung Kwak
Oct 8, 2013·Journal of the American Veterinary Medical Association·Beth W EisenbergNicholas J Horton
May 1, 2021·International Journal of Molecular Sciences·Maryam Mahjoubin-TehranAmirhossein Sahebkar

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