Abstract
Atherosclerosis is a chronic inflammatory process occurring in the walls of arteries, in large part due to the accumulation of inflammatory cells. This study was conducted to determine the effect of nuclear factor (NF)-κB decoy oligodeoxynucleotide (ODN) in an atherosclerosis animal model. The mice received i.p. injections of lipopolysaccharide (LPS, 2 mg/kg) three times a week to induce atherosclerotic change, and fed an atherogenic diet for 12 weeks. NF-κB decoy ODN (0.4 mg/kg) was injected into the tail vein. Treatment with NF-κB decoy ODN decreased pro-inflammatory cytokines, tumour necrosis factor (TNF)-α and interleukin (IL)-1β and inflammatory markers, vascular adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1, in the LPS/Fat-induced mice. In addition, the expression of proteins related to fibrosis, transforming growth factor (TGF)-β1 and fibronectin were markedly decreased in the mice treated with NF-κB decoy ODN compared with the LPS/Fat-induced mice without decoy ODN treatment. These data suggest that NF-κB decoy ODN may exert an inhibitory effect on the expression levels of pro-inflammatory cytokines and cell adhesion molecules in atherosclerotic mice.
References
Jul 27, 1999·Circulation Research·K IiyamaM I Cybulsky
Apr 20, 2000·The Journal of Clinical Investigation·E A PodrezS L Hazen
May 16, 2000·Circulation Research·H MatsushitaT Ogihara
Nov 9, 2000·The Journal of Clinical Investigation·M J Mann, V J Dzau
Nov 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R De MartinJ A Schmid
Jan 3, 2001·The Journal of Clinical Investigation·P P Tak, G S Firestein
Mar 10, 2001·Cell·C K Glass, J L Witztum
Oct 3, 2001·The Journal of Thoracic and Cardiovascular Surgery·T UenoH Matsuda
Mar 16, 2002·Gene Therapy·S YoshimuraT Ogihara
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Hirokazu KiriiMitsuru Seishima
Nov 18, 2004·Journal of Lipid Research·Godfrey S Getz
Jan 28, 2005·Molecular Pharmacology·Delphine BaetzLorrie A Kirshenbaum
Apr 13, 2005·Atherosclerosis·Hirotoshi OhtaMitsuru Seishima
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Aug 30, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuriko HiguchiMitsuru Hashida
Apr 8, 2006·Physiological Reviews·Alain Tedgui, Ziad Mallat
Oct 13, 2007·Journal of Ethnopharmacology·Ki Mo KimJeong Euy Park
Oct 31, 2007·Circulation·Marit WesterterpPatrick C N Rensen
Nov 23, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Clarisse Cuaz-PérolinMustapha Rouis
Jan 3, 2009·Experimental and Molecular Pathology·Kyung-Hyun KimKwan-Kyu Park
Citations
Dec 11, 2013·Clinical & Developmental Immunology·Jing-qin NiYun Zhang
Jul 19, 2011·Journal of the American Chemical Society·Jeane M GovanAlexander Deiters
May 27, 2015·International Journal of Molecular Sciences·Sung Won Youn, Kwan-Kyu Park
Jul 23, 2011·Cellular Immunology·John J Haddad, Nisreen E Abdel-Karim
May 31, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Soo-Jung KimKwan-Kyu Park
Jul 24, 2014·Preventive Nutrition and Food Science·Mi Joung KimHo-Kyung Kwak
Nov 4, 2017·DNA and Cell Biology·Yanmei TanZhonghua Yuan
Jul 14, 2018·Cell Transplantation·Wei ZhangQuan Zhou
Nov 30, 2011·Nutrition Research and Practice·Mi Joung KimHo-Kyung Kwak
Apr 28, 2012·Inflammation·Jinwei TianBo Yu
Oct 8, 2013·Journal of the American Veterinary Medical Association·Beth W EisenbergNicholas J Horton
Jan 9, 2020·Experimental Physiology·Chuanfang LiZesheng Xu
Oct 31, 2012·Basic & Clinical Pharmacology & Toxicology·Woo-Ram LeeKwan-Kyu Park
May 1, 2021·International Journal of Molecular Sciences·Maryam Mahjoubin-TehranAmirhossein Sahebkar