PMID: 7541148Jan 1, 1995Paper

Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice

Rheumatology International
L AloeP Tirassa

Abstract

We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-alpha (TNF-alpha) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammatory markers in joint arthritis.

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Citations

Jul 13, 2002·The Journal of Pathology·Anthony J FreemontShant Kumar
Aug 9, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yan ShiXiaohong Lv
Nov 24, 1999·Annals of Surgery·H FriessM W Büchler
Jan 5, 2001·Expert Opinion on Investigational Drugs·S Brunelleschi
Sep 7, 2007·Annals of the New York Academy of Sciences·Malin JohanssonSture Forsgren
Oct 19, 2011·Journal of Shoulder and Elbow Surgery·Yinghua XuGeorge A C Murrell
Sep 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Z Xiang, G Nilsson
Apr 10, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Nicola Di GirolamoBrett R Gardner

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