PMID: 2484596Jul 1, 1989Paper

Effect of nickel chloride on hepatic lipid peroxidation and glutathione concentration in mice

Biological Trace Element Research
H R Andersen, O Andersen

Abstract

Intraperitoneal administration of nickel chloride enhanced hepatic lipid peroxidation (HLP) in 6-wk-old and 8-12-wk-old male CBA-mice but not in 3-wk-old mice. Nickel chloride administration depleted hepatic GSH in 8-12-wk-old mice but not in the younger age groups. After 300 mumol NiCl2/kg mortality occurred among 8-12-wk-old mice but not among the younger mice. Stimulation of GSH synthesis by administration of L-2-oxothiazolidine-4-carboxylate reduced nickel chloride induced mortality and HLP. Reduction of GSH synthesis by administration of buthionine sulfoximine (BSO) did not, however, enhance the toxicity of nickel chloride. This might be owing to chelation of the Ni(II)-ion by BSO. The results demonstrate age dependency and a protective effect of enhanced GSH synthesis in nickel chloride stimulated HLP.

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Citations

Feb 1, 1994·Cell Biology and Toxicology·M Sugiyama
May 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M IscanM Iscan
Apr 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M H GrantR Bertrand
Jan 13, 2009·Journal of Occupational and Environmental Medicine·Jiin-Chyuan John LuoWu-Shiun Shen
Oct 30, 1998·Zentralblatt für Veterinärmedizin. Reihe A·M P Popova, C S Popov
Jan 1, 1995·Cancer Investigation·K S Kasprzak
Aug 1, 1992·Journal of Applied Toxicology : JAT·K ArsalaneH F Hildebrand
Apr 15, 2008·Chemico-biological Interactions·L Pari, A Prasath
May 7, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ole Andersen, Jan Aaseth
Mar 13, 2003·Archives of Toxicology·Chang-Yu ChenShu-Fang Yen
Jul 9, 2014·Eukaryotic Cell·Yasuhiro TakenakaTakuya Awata
Sep 5, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Kusal K DasM S Biradar

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