Effect of nicotine on endothelium-dependent arteriolar dilatation in vivo

The American Journal of Physiology
W G Mayhan, K P Patel

Abstract

Smoking is a primary risk factor in coronary and peripheral vascular disease. However, the precise component of cigarette smoke that contributes to the pathogenesis of vascular disease remains unclear. The goal of this study was to determine the effect of nicotine on endothelium-dependent dilatation of peripheral resistance arterioles in vivo. We measured the diameter of resistance arterioles (approximately 50 microns in diameter) contained within the microcirculation of the hamster cheek pouch in response to endothelium-dependent (acetylcholine and ADP) and -independent (nitroglycerin) agonists before and after an intravenous infusion of vehicle or two concentrations of nicotine. Acetylcholine, ADP, and nitroglycerin produced a dose-related dilatation of the cheek pouch arterioles under control conditions. Endothelium-dependent, but not -independent, dilatation of arterioles was modestly impaired by an infusion of a low concentration of nicotine (1.0 microgram.kg-1.min-1). Infusion of a higher concentration of nicotine (2 micrograms.kg-1.min-1), which increased the plasma level of nicotine to 14 +/- 1.6 ng/ml, produced a profound selective impairment in endothelium-dependent vasodilatation. We suggest that elevations in plasma...Continue Reading

Citations

Sep 27, 2003·American Journal of Physiology. Heart and Circulatory Physiology·F MocciaD J Adams
Aug 26, 2006·Basic & Clinical Pharmacology & Toxicology·Hong-Li LuoYong-Xiao Cao
Aug 14, 2010·Journal of Applied Physiology·William G MayhanKaushik P Patel
Jan 15, 2013·Mediators of Inflammation·Nohra ChalouhiAaron S Dumont
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·V M MillerR D Hurt
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Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C E BlackC Y Pang
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Jan 19, 2021·American Journal of Physiology. Renal Physiology·Edgar A JaimesLeopoldo Raij

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