PMID: 9184797May 1, 1997Paper

Effect of nicotine on the intimal hyperplasia after endothelial removal of the rabbit carotid artery

General Pharmacology
H HamasakiH Azuma

Abstract

1. The present experiments were designed to investigate the effect of long-term oral nicotine (10 mg/200 ml/kg/day for 7 weeks) on the intimal hyperplasia after endothelial removal of the rabbit carotid artery. 2. The plasma concentrations of nicotine were determined to be 11.7-12.5 ng/ml during the term of administration and corresponded to the plasma levels in human smokers. 3. Six weeks after the endothelial removal, light microscopy revealed a marked intimal hyperplasia. Administration of nicotine tended to accelerate the intimal hyperplasia, which was estimated by comparing the histological findings, DNA content and wet weight of the vessel wall. 4. Acetylcholine- and A23187-induced endothelium-dependent relaxations were greatly impaired in the hyperplastic artery strips. The impairment of relaxations tended to be accelerated in the nicotine group. Sodium nitroprusside-induced relaxation was not different between the control and the hyperplastic artery strips and remained unaffected in the nicotine group. 5. The concentrations of endogenous nitric oxide (NO) synthesis inhibitors, NG-monomethyl-L-arginine (L-NMMA) and asymmetrical NG,NG-dimethyl-L-arginine (ADMA) were significantly more increased in the regenerated endothel...Continue Reading

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Citations

Apr 29, 2010·Current Atherosclerosis Reports·Andrew L PipeRobert D Reid
Jul 10, 2010·Cardiovascular Research·Roberto I Vazquez-PadronSi M Pham
Jun 17, 2009·Molecular Human Reproduction·Emiko ItoHiroshi Azuma
Sep 6, 2000·International Journal of Experimental Pathology·R Michael Pittilo
Nov 3, 2009·European Journal of Pharmacology·Anna L B Jacob-FerreiraJose E Tanus-Santos
Jan 15, 2005·Progress in Neurobiology·C Gotti, F Clementi
Apr 9, 2009·Clinical Cardiology·Ozgur CiftciHaldun Muderrisoglu
Mar 4, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Andrzej SobczakMaciej Lukasz Goniewicz
Sep 9, 2006·Biochemical and Biophysical Research Communications·De-Jian JiangYuan-Jian Li
Aug 23, 2006·Hypertension·Jan T KielsteinM Christopher Adams
Oct 5, 2001·The Journal of Urology·K T McVaryUNKNOWN Subcommittee on Smoking and Erectile Dysfunction Socioeconomic Committee, Sexual Medicine Society of North America
Dec 18, 2008·Canadian Journal of Physiology and Pharmacology·Zhe ZhangYuan-Jian Li
May 16, 2020·Vascular·Yuan-Hsi TsengYao-Hsu Yang
Feb 18, 2021·Acta Physiologica·Anna K WhiteheadXinping Yue

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