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Effect of nicotine on the lower esophageal sphincter. Studies on the mechanism of action

Gastroenterology

Jul 1, 1975

Satish Rattan, Raj K Goyal

PMID: 1150020

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Abstract

Intravenous administration of nicotine sulfate caused a dose-dependent reduction in the lower exophagel sphincter pressure in anesthetized opossums. The maximal reduction in pressure of 85.0 +/- 2.6% was observed with a dose of 50 mug per kg. The effect of 50 mug per kg was not antagoni...read more

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Hexamethonium Compounds
V-Serp
Vagotomy
Sphincter
Propranolol
Intra-Arterial Injections
Inferior Esophageal Sphincter Structure
Didelphidae
Biochemical Pathway
Drug Kinetics
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Effect of nicotine on the lower esophageal sphincter. Studies on the mechanism of action

Gastroenterology

Jul 1, 1975

Satish Rattan, Raj K Goyal

PMID: 1150020

DOI:

Abstract

Intravenous administration of nicotine sulfate caused a dose-dependent reduction in the lower exophagel sphincter pressure in anesthetized opossums. The maximal reduction in pressure of 85.0 +/- 2.6% was observed with a dose of 50 mug per kg. The effect of 50 mug per kg was not antagoni...read more

Mentioned in this Paper

Hexamethonium Compounds
V-Serp
Vagotomy
Sphincter
Propranolol

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