PMID: 24353732Dec 20, 2013Paper

Effect of Nicotinic Acid (Vitamin B3 or Niacin) on the lipid profile of diabetic and non - diabetic rats

Pakistan Journal of Medical Sciences
Talmeez Zeb ShahM H Qazi

Abstract

To determine the efficacy of nicotinic acid on the lipid profile of diabetic and non diabetic rats. This was an experimental study done at the Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan between May 2010 to July 2010. Nicotinic acid was administered to a hypercholesterolemic group and a hypercholesterolemic + diabetic Group of Albino rats for 42 days and response to therapy was recorded on day 21 and day 42 of the experiment. Comparison among these two groups as well as three control groups was determined by Analysis of Variance (ANOVA) and differences were considered significant at (P<0.05). A total of 50 rats were included in the study. Lipid profile of the hypercholesterolemic group as well as hypercholesterolemic + diabetic group as compared with the control groups showed highly significant improvement on the day 21 and day 42 of the experiment. The values of serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) cholesterol and total lipids (TL) showed highly significant decrease whereas serum high density lipoprotein (HDL) cholesterol showed highly significant increase. Nicotinic acid is the most effective agent available in increasing HDL cholesterol and l...Continue Reading

Citations

Jul 22, 2014·Alcoholism, Clinical and Experimental Research·Kusum K Kharbanda
Aug 23, 2018·Journal of Cosmetic Dermatology·Mohammad Ali NilforoushzadehMahsa Mollapour Sisakht
Mar 24, 2020·Open Heart·James J DiNicolantonioJames OKeefe

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