Effect of Nicotinic acid/Laropiprant in the lipoprotein(a) concentration with regard to baseline lipoprotein(a) concentration and LPA genotype

Metabolism: Clinical and Experimental
Ana CenarroFernando Civeira

Abstract

Lipoprotein(a) [Lp(a)] is a lipoprotein in which apolipoproteinB-100 is linked to apolipoprotein(a) [apo(a)]. Significant variation in Lp(a) concentration is specific to LPA gene, which codes for apo(a). Nicotinic acid (NA) is used for treatment of dyslipidemias, and the lowering effect of NA on Lp(a) has been previously reported. To evaluate the Lp(a) lowering effect of 1g/20mg and 2g/40mgday of Nicotinic acid/Laropiprant in subjects with different baseline Lp(a) concentrations and depending on the LPA genotype. In an open-label, 10-week study, 1g/20mgday of NA/Laropiprant for 4weeks followed by 6weeks of 2g/40mgday conducted at 3 centers in Spain, 82 subjects were enrolled. Patients were studied at baseline and at the end of both treatment periods and were enrolled in three groups: normal Lp(a) (<50mg/dL), high Lp(a) (50-120mg/dL) and very high Lp(a) (>120mg/dL). The LPA genetic polymorphism was analyzed by a real-time PCR. There was a significant difference in LPA genotypes among Lp(a) concentration groups and an inverse and significant correlation between baseline Lp(a) concentration and LPA genotype was found (R=-0.372, p<0.001). There were a significant decrease in total cholesterol, triglycerides, LDL cholesterol, apo B ...Continue Reading

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Citations

Dec 4, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Hayato TadaKenshi Hayashi
May 14, 2016·Metabolism: Clinical and Experimental·Pei WangChao-Yu Miao
Sep 16, 2015·Canadian Journal of Physiology and Pharmacology·Ulrich Julius
Dec 30, 2016·International Journal of Clinical Practice·Panagiotis AnagnostisDimitrios G Goulis
Dec 8, 2015·Journal of Lipid Research·Julian C van CapelleveenErik S G Stroes
Feb 2, 2019·Current Pharmaceutical Design·Michele ScognamiglioClaudio Napoli
Feb 6, 2015·Molecular Systems Biology·Yansheng LiuRuedi Aebersold
Jul 9, 2020·Journal of Clinical Medicine·Maria Francesca GrecoMassimiliano Ruscica

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