Effect of nifedipine on oesophageal motility and gastric emptying

Digestion
J N BlackwellR C Heading

Abstract

Manometric studies have been performed to determine the effect of nifedipine on lower oesophageal sphincter (LOS) pressure and distal oesophageal motility in healthy subjects, in patients with diffuse oesophageal spasm, and in a patient with achalasia. Significant reductions in LOS pressure and in the amplitude of peristaltic oesophageal contractions were observed. In the patients with diffuse oesophageal spasm the amplitude and frequency of non-peristaltic (spasm) contractions were also reduced. Nifedipine did not significantly influence gastric emptying rates of solid and liquid components of a test meal in normal subjects nor in patients who had undergone gastric surgery.

Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·I Konrad-DalhoffJ Kuhlmann
Jun 1, 1993·Digestive Diseases and Sciences·G ChiarioniI Vantini
Sep 1, 1991·Digestive Diseases and Sciences·R T YavorskiP W Blue
Apr 1, 1992·Digestive Diseases and Sciences·A J SmoutD O Castell
Mar 1, 1991·Digestive Diseases and Sciences·M Traube
Aug 1, 1985·Digestive Diseases and Sciences·M TraubeR W McCallum
Jan 1, 1989·Digestive Diseases and Sciences·T K Chaudhuri, S Fink
May 1, 1988·Digestive Diseases and Sciences·R SantanderJ E Valenzuela
Jan 1, 1987·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J C CoelhoK Messmer
Feb 1, 1996·Diseases of the Colon and Rectum·E ChrysosS J Vassilakis
Jul 1, 1996·Digestive Diseases and Sciences·M L Allen, A J DiMarino
Jan 1, 1993·Dysphagia·H D Allescher, W J Ravich
Mar 1, 1989·Journal of General Internal Medicine·A K Rustgi, S Chopra
Jun 1, 1988·Disease-a-month : DM·J B Nelson, D O Castell
Oct 1, 1993·Pharmacology & Therapeutics·F De PontiG Frigo
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·L R CoiaJ E Tepper
Apr 19, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M Storr, H D Allescher
Nov 11, 1982·The New England Journal of Medicine·H A DaviesA Henderson
Mar 1, 1990·Journal of Gastroenterology and Hepatology·R H Holloway
Mar 1, 1986·British Medical Journal·J Powell-TuckR A Parkins
Nov 1, 1983·Gut·G Vantrappen, J Janssens
Jan 1, 1984·Gut·J N Blackwell, D O Castell
Jul 17, 2001·Journal of Clinical Pharmacology·S L ChowJ L Izzo
Apr 18, 2015·Expert Opinion on Drug Delivery·Božena BürmenMarija Bogataj
Aug 30, 2008·Disease-a-month : DM·Sami R Achem
Mar 15, 2011·Journal of Clinical Pharmacy and Therapeutics·A HamadaK Nakashima
Nov 15, 2011·Alimentary Pharmacology & Therapeutics·T HershcoviciR Fass
Apr 25, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Li, J D Z Chen
Nov 26, 2008·Gastroenterology Clinics of North America·Sami R Achem
Aug 1, 1982·Current Problems in Surgery·C G Bremner
Jan 25, 1985·The American Journal of Cardiology·D O Castell
Nov 1, 1989·The British Journal of Surgery·R C Stuart, T P Hennessy
Mar 1, 1985·The Journal of Pharmacy and Pharmacology·F J Morales-OlivasJ Esplugues
May 1, 1985·The British Journal of Surgery·R G Buick, L Spitz
Dec 1, 1988·Journal of Clinical Pharmacy and Therapeutics·M Deakin, J G Temple
Apr 6, 2004·Gastroenterology Clinics of North America·Sami R Achem
May 27, 1992·The American Journal of Medicine·S R Achem, B E Kolts
Jun 6, 2013·Emergency Medicine International·Yasir Mohammed Khayyat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta gastroenterologica Latinoamericana
Teodoro Córdova-FragaMartha Hernández-González
Digestive Diseases and Sciences
M L Allen, A J DiMarino
European Journal of Gastroenterology & Hepatology
B L Weusten, A J Smout
© 2021 Meta ULC. All rights reserved