PMID: 3321539Oct 1, 1987Paper

Effect of nifedipine on serum theophylline concentrations and asthma control

Thorax
S R SmithM J Kendall

Abstract

The effect of adding slow release nifedipine to oral theophylline has been studied in eight patients with stable but symptomatic asthma, a double blind placebo controlled crossover protocol being used. No change in asthma control occurred during the nifedipine treatment period as assessed by serial peak flow measurements and symptom scores. Serum theophylline concentrations were significantly lower after nifedipine than after placebo (6.8 v 9.7 micrograms/ml) and in three patients were well below the therapeutic range (less than 4 micrograms/ml).

References

Jul 1, 1978·Clinical Pharmacokinetics·R I Ogilvie
Apr 1, 1986·British Journal of Clinical Pharmacology·S H JacksonP Turner
Jan 1, 1985·British Journal of Clinical Pharmacology·P J Barnes
Jul 1, 1984·Annals of Internal Medicine·M BukowskyjP W Munt
Aug 1, 1984·Thorax·A M LeverG J Gibson
Aug 1, 1983·Respiration Physiology·J F SouhradaM Souhrada

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Citations

Jan 1, 1989·European Journal of Clinical Pharmacology·T BratelR Dahlqvist
Jan 1, 1991·Fundamental & Clinical Pharmacology·E YilmazL Eroğlu
Feb 1, 1990·Pharmacology & Toxicology·J E Nielsen-KudskA C Johannessen

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