Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus

Phytotherapy Research : PTR
Akram KooshkiMohammad Miri

Abstract

This study aimed to evaluate the effects of Nigella sativa oil on serum level of systemic inflammation, oxidative stress, fasting blood glucose (FBG), and lipid profile in patients with type 2 diabetes mellitus (T2DM). This double-blind randomized clinical trial study was based on 50 patients with T2DM. Patients were allocated randomly to either N. sativa oil or placebo groups. The intervention group received 1,000 mg N. sativa oil as two capsules, daily for 8 weeks, whereas the placebo group received a corresponding placebo. At baseline and the end of the study, 5 ml blood was collected from each patient after 14-hour fasting for measuring serum C-reactive protein (hs-CRP), malondialdehyde (MDA), FBS, and lipid profile. Analyses covariance was performed to compare investigated parameters between two groups, controlled for relevant covariates. Using N. sativa supplement was significantly associated with decrease in FBS (p < .001), triglyceride (p < .001), total cholesterol (p < .001), low-density lipoprotein cholesterol (p < .001), serum hs-CRP, MDA (p < .001) and increase in serum level of high-density lipoprotein cholesterol (p < .001) in intervention group compared with placebo group. Nigella sativa oil supplement has cardio...Continue Reading

References

Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·A JagerC D Stehouwer
Feb 17, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M N Nagi, M A Mansour
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Philip GreenlandPeter W Wilson
Nov 14, 2007·Journal of Clinical Epidemiology·George F BormWim A J G Lemmens
Mar 9, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Jasleen K DuggalRohit Arora
Nov 16, 2011·The American Journal of Chinese Medicine·Mohammad Akram Randhawa, Mastour Safar Alghamdi
Dec 12, 2012·Journal of Family & Community Medicine·Huda KaatabiAli I Al-Sultan
Feb 11, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Muhammad Tauseef SultanVincenzo De Feo
Jul 3, 2015·Journal of Endocrinological Investigation·S AsgaryN Goli-Malekabadi
Feb 3, 2016·Global Spine Journal·Daniel C NorvellJens R Chapman
Feb 16, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amirhossein SahebkarSimona Bo
Apr 22, 2016·Immunological Investigations·Sorayya KheirouriMohammad Alizadeh
Jun 16, 2016·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Ebrahim ShirzadehMaryam Mohammadi
Sep 1, 2016·Oxidative Medicine and Cellular Longevity·Mahmoud BalbaaAbdel Wahab Mandour
Dec 3, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Alireza Mohtashami, Mohammad Hasan Entezari
Nov 21, 2017·Complementary Therapies in Medicine·Reza Daryabeygi-KhotbehsaraKurosh Djafarian
Feb 27, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Karima Bensiameur-TouatiSouhila Aouichat-Bouguerra
Jun 2, 2018·Mediators of Inflammation·Mariana Mendes-Braz, Joilson O Martins
Nov 18, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mahdi SepidarkishJavad Heshmati
Sep 30, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Javad HeshmatiMahdi Sepidarkish

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.