Effect of nitric oxide inhibition on blood pressure and renal sodium handling: a dose-response study in healthy man

Clinical and Experimental Hypertension : CHE
Thomas LarsenErling Bjerregaard Pedersen

Abstract

Nitric oxide (NO) is a ubiquitous vasodilator and an important regulator of renal sodium excretion. To further investigate the role of NO in renal sodium handling, we studied the effects of the NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), in a crossover dose-response study. During NO inhibition mean arterial pressure increased dose-dependently and reached a plateau after 20 minutes of infusion. On the contrary, the fractional excretion of sodium was reduced equally in all three L-NMMA doses. This indicates that sodium excretion is highly sensitive to even small changes in renal NO bioavailability in healthy human.

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Citations

Apr 5, 2014·British Journal of Clinical Pharmacology·Frank Holden MoseErling Bjerregaard Pedersen
Mar 18, 2015·British Journal of Clinical Pharmacology·Frank H MoseErling B Pedersen
Nov 22, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Frank H MoseErling B Pedersen
May 12, 2017·American Journal of Physiology. Renal Physiology·Jeppe Bakkestroem RosenbaekJesper Noergaard Bech
Feb 10, 2017·American Journal of Physiology. Renal Physiology·Alberto MontanariDavid Z I Cherney
May 10, 2013·American Journal of Physiology. Renal Physiology·Alberto MontanariDavid Z Cherney

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