PMID: 8941531Nov 1, 1996Paper

Effect of nitric oxide synthase inhibition on cardiorespiratory responses in the conscious rat

Journal of Applied Physiology
David GozalS M Littwin

Abstract

Nitric oxide synthase (NOS) blockade was used to test the cardioventilatory responses to hypercapnia and hypoxia in freely behaving animals. Chronically instrumented adult Sprague-Dawley rats were studied before and after intravenous administration of either 100 mg/kg of NG-nitro-L-arginine methyl ester (L-NAME), a nonspecific NOS blocker, or 10 mg/kg of S-methyl-L-thiocitrulline (SMTC), a selective neural NOS inhibitor. L-NAME injection induced sustained blood pressure (BP) elevation with transient tachycardia and increased minute ventilation (VE), which returned to baseline within minutes. SMTC elicited similar, although transient, BP increases; however, heart rate and VE decreased. L-NAME and SMTC did not modify overall steady-state hypercapnic responses. In control conditions, hypoxia induced early VE increases with further VE enhancements at 30 min. L-NAME increased the early VE response to 10% O2 but induced late VE reductions in hypoxia. SMTC did not change early VE responses but induced marked reductions in the later VE hypoxic responses. In control animals, hypoxia induced a significant heart rate increase. This increase was absent during the early response after SMTC and was followed in both L-NAME- and SMTC-treated a...Continue Reading

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Citations

Oct 20, 1998·Journal of Toxicology. Clinical Toxicology·A EisenmanR Enat
Sep 8, 1998·Journal of Applied Physiology·R C Barros, L G Branco
Apr 6, 2000·Journal of Applied Physiology·D D KlineN R Prabhakar
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