Effect of nitrite delivered in saliva on postprandial gastro-esophageal function.

Scandinavian Journal of Gastroenterology
J P SeenanK E L McColl

Abstract

Acid reflux produces troublesome symptoms (heartburn) and complications including esophagitis, Barrett's esophagus, and adenocarcinoma. Reflux occurs due to excessive and inappropriate relaxation of the lower esophageal sphincter. An important mediator of this is nitric oxide, high concentrations of which are generated within the lumen when swallowed saliva meets gastric acid. Saliva contains nitrite, derived from the enterosalivary recirculation of dietary nitrate, which is reduced to nitric oxide by gastric acid. The aim of this study was to investigate whether salivary nitrite contributes to dysfunction of the lower esophageal sphincter. In 20 volunteers, studies of gastro-esophageal function were performed on four separate days, following consumption of a standardized meal, with saliva nitrite concentrations modified differently each day by intra-oral nitrite infusion. The infusions produced an appropriate range in saliva nitrite concentrations, from below to well above the physiological range. The standardized meal induced expected physiological changes in gastro-esophageal function confirming the recordings were sensitive and robust. Esophageal acid exposure (primary outcome) was similar on each study day. Secondary outco...Continue Reading

References

Dec 1, 1976·Food and Cosmetics Toxicology·S R TannenbaumD Fett
Feb 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P M BosT Ockhuizen
Jul 1, 1988·Gut·F Johnsson, B Joelsson
Oct 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Bartholomew, M J Hill
Jun 1, 1996·European Journal of Gastroenterology & Hepatology·G N TytgatM Wienbeck
Mar 27, 1997·The New England Journal of Medicine·R K Mittal, D H Balaban
Aug 3, 2000·International Journal of Epidemiology·A A BotterweckP A van Den Brandt
Dec 16, 2000·Digestive Diseases and Sciences·D P HirschG E Boeckxstaens
Jan 5, 2002·The American Journal of Gastroenterology·P L RheeK W Choi
Mar 21, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B E ViramontesA R Zinsmeister
May 10, 2003·Scandinavian Journal of Gastroenterology·K IijimaK E L McColl
Oct 12, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Giovanni SarnelliJan Tack
Jan 18, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sudip K GhoshPeter J Kahrilas
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Jonathan J ManningKenneth E L McColl

❮ Previous
Next ❯

Citations

May 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcin MagierowskiTomasz Brzozowski
May 28, 2014·Journal of Gastroenterology and Hepatology·Katsunori Iijima, Tooru Shimosegawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.