Effect of nitrogen dioxide exposure on allergic asthma in a murine model

Chest
Iftikhar HussainJoel Kline

Abstract

The purpose of this study was to examine the effects of NO(2), a major component of air pollution, on airway eosinophilic inflammation and bronchial hyperreactivity, using a mouse model of asthma. BALB/c mice (eight mice per experimental group) were studied in a basic research laboratory at the University of Iowa. Using a standard murine model of asthma, BALB/c mice were sensitized to ovalbumin (OVA) by intraperitoneal (IP) injections (days 1 and 7) and were challenged with aerosolized OVA (days 13 and 14). Some mice were exposed to NO(2) (2 ppm) in an exposure chamber for 24 h before undergoing OVA aerosol challenge. A control group was exposed to OVA alone. The outcomes assessed included airway inflammation, bronchial hyperreactivity to inhaled methacholine, and goblet cell hyperplasia. We found that NO(2) exposure modestly increased airway neutrophilia but not airway eosinophilia in OVA-exposed mice. These mice exhibited epithelial damage and loss of epithelial mucin. Surprisingly, nonspecific bronchial hyperreactivity (ie, enhanced pause index) was not increased, although baseline smooth muscle tone was increased (p < 0.05) in the mice exposed to NO(2). These data indicate that relatively short-term (24 h) exposure to NO(2)...Continue Reading

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Citations

Aug 1, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G H DongE Trevathan
Oct 2, 2009·Journal of Endocrinological Investigation·B BoggiaM De Rosa
May 25, 2012·Journal of Hazardous Materials·Hongyan LiGuangke Li
Jun 12, 2012·Environmental Research·Janvier GasanaEdgar Ramos Vieira
May 3, 2014·Journal of Toxicology and Environmental Health. Part a·Renate HochscheidBernd Müller
Oct 8, 2017·Environmental Science and Pollution Research International·Ming HanNan Sang
Aug 9, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Matthew E PoynterYvonne Janssen-Heininger

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