Effect of NMDA antagonists, an NMDA agonist, and serotonin depletion on acute tolerance to ethanol

Pharmacology, Biochemistry, and Behavior
J M KhannaH Kalant

Abstract

The effect of N-methyl-D-aspartate (NMDA) antagonists [dizocilpine, (+)MK-801, and ketamine], an NMDA agonist (D-cycloserine) and of brain serotonin (5-HT) depletion with p-chlorophenylalanine (p-CPA) on acute tolerance to ethanol was examined, using the tolerance model proposed by Radlow [Psychopharmacology 114 (1994) 1-8] and Martin and Moss [Alcohol Clin Exp Res 17 (1993) 211-216]. This model is based on the concept of a linear increase of acute tolerance with time; the rate of acute tolerance development is the slope of the output function that relates blood alcohol concentrations (BACs) and intoxication. Pretreatment with NMDA antagonists inhibited the development of acute tolerance to ethanol, whereas pretreatment with D-cycloserine enhanced it. Depletion of 5-HT by p-CPA also blocked acute tolerance to ethanol. These results on acute tolerance are similar to those previously found on rapid and chronic tolerance to ethanol.

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Citations

Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Anthony F PizonDale Bikin
Jun 5, 2007·Psychopharmacology·Jose Inácio LemosGina Struffaldi Morato
Sep 10, 2011·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Myoung-Sun RohUng Gu Kang
Jun 14, 2008·The Journal of Pharmacology and Experimental Therapeutics·Wei HuBoris Tabakoff
Jan 3, 2016·Pharmacology, Biochemistry, and Behavior·Sylwia TalarekSylwia Fidecka
Nov 21, 2008·Maturitas·Luiz Gustavo A ChuffaFrancisco E Martinez
Nov 11, 2008·Pharmacology, Biochemistry, and Behavior·Daniel RialGina Struffaldi Morato
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Sandra L Morzorati, Robert B Stewart
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Karen H BergerMonica S Moore
Oct 28, 2006·Alcoholism, Clinical and Experimental Research·Elena I Varlinskaya, Linda P Spear
Jun 21, 2008·Alcoholism, Clinical and Experimental Research·Benjamin PalachickAndrew Holmes
Feb 21, 2006·Brain Research Reviews·Gyongyi Horvath, Gabriella Kekesi
Nov 10, 2004·Brain Research·Gabriella KekesiGyongyi Horvath
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