Effect of NMDA antagonists on rapid tolerance to benzodiazepines

Brain Research Bulletin
J M KhannaG Shah

Abstract

We have reexamined the effect of NMDA antagonists [(+)MK-801 and ketamine] on rapid tolerance to chlordiazepoxide. (+)MK-801 and ketamine blocked the development of rapid tolerance to chlordiazepoxide, but this effect was dependent on the dose ratio of the NMDA antagonist to that of the benzodiazepine used to produce rapid tolerance. Furthermore, NMDA antagonists blocked both learned and unlearned tolerance to chlordiazepoxide. It appears that in addition to impairment of memory and learning, NMDA antagonists may also influence some other mechanism involved in the production of drug-tolerance.

References

May 1, 1992·Pharmacology, Biochemistry, and Behavior·M G De MontisA Tagliamonte
Feb 1, 1992·Brain Research Bulletin·J M KhannaA Chau
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·J M KhannaH Kalant
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·S E File, C Fernandes
Feb 9, 1993·European Journal of Pharmacology·P H WuH Kalant

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Citations

Nov 11, 2009·Bulletin of Experimental Biology and Medicine·V I KresyunE V Kobolev
Jul 31, 2001·Journal of Psychoactive Drugs·K L Jansen, R Darracot-Cankovic
Apr 27, 2012·Advances in Pharmacological Sciences·Christiaan H Vinkers, Berend Olivier
Jan 3, 2016·Pharmacology, Biochemistry, and Behavior·Sylwia TalarekSylwia Fidecka

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