PMID: 9168485Mar 1, 1997Paper

Effect of NMDA on the activity of cortical glutaminergic structures in delayed visual differentiation in monkeys

Neuroscience and Behavioral Physiology
K N DudkinI V Chueva

Abstract

The effect of intracortical perfusion with the glutamate agonist NMDA on visual recognition and short-term memory, as well as an on the responses of visual cortex neurons, were studied in rhesus macaques. A microdialysis technique was used in combination with multichannel microelectrode recording of single cortical cells in the immediate vicinity of the dialysis tube in a behavioral experiment in which the monkey had to solve a task involving delayed visual differentiation of stimuli of different colors. NMDA altered the characteristics of recognition in monkeys. The duration of information storage in short-term memory was increased significantly (2-4-fold), and there was a significant reduction in the motor response time for all delay periods. These changes were accompanied by a significant rearrangement of neuron activity in the visual cortex at all stages of the behavioral task. At different stages of the task, 70-85% of the neurons showed 2-5-fold increases in activity, while 6-20% showed reductions in activity. These results demonstrate an involvement of visual cortex glutaminergic structures in the process of visual recognition and short-term memory, as well as a nootropic effect obtained by intracortical administration o...Continue Reading

References

Jan 1, 1989·Annual Review of Pharmacology and Toxicology·J T Wroblewski, W Danysz
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Citations

Dec 29, 2000·Nature Neuroscience·D DurstewitzT J Sejnowski
Jun 3, 2006·Cerebral Cortex·Daniel Durstewitz, Thomas Gabriel
May 16, 2019·Nature Reviews. Neuroscience·Kartik K Sreenivasan, Mark D'Esposito

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