Effect of NMDA receptor blockade on melatonin and activity rhythm responses to a light pulse in rats

Brain Research Bulletin
S A Rowe, D J Kennaway

Abstract

The possible role of the excitatory amino acids as mediators of the acute suppression and subsequent delay by light of pineal melatonin production was studied in rats using the NMDA receptor antagonist MK-801. Saline or MK-801 in doses up to 3 mg/kg (IP), was administered 15 min before a 15-min light pulse (200 lx), 4 h after dark onset, and the excretion of 6-sulphatoxymelatonin (aMT.6S) determined. Under these conditions saline injected/light exposed animals exhibited an acute, total but transient suppression of urinary aMT.6S excretion and a delay in the onset of aMT.6S the following night of 1.5 +/- 0.2 h. MK-801 failed to block either the acute or phase delaying effect of light (onset delayed by 2.2 +/- 0.4 h). Pretreatment with MK-801 (3 mg/kg) failed to block the effects of shorter, less intense light pulses 15 min before the pulse (e.g., 1 min/2 lx; onset delayed by 2.0 +/- 0.4 h following saline, 1.5 +/- 0.1 h following MK-801) or 60 min before a short duration low intensity pulse. In other experiments MK-801 (1 and 3 mg/kg) failed to affect aMT.6S excretion when injected in the dark at the time of lights out or 4 h after dark onset. NMDA (10 and 30 mg/kg) injection at the time of lights out or 4 h after darkness did n...Continue Reading

References

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Citations

Nov 20, 2003·Brain Research. Molecular Brain Research·Tamara J VarcoeAthena Voultsios
Oct 24, 1998·Clinical and Experimental Pharmacology & Physiology·D J Kennaway
Dec 28, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Gregory A CaryAndrea R Tilden
Jul 26, 2011·Molecular and Cellular Endocrinology·Jimo BorjiginAnda-Alexandra Calinescu
Sep 16, 2014·Developmental Neurobiology·Maryline LecointreIsabelle Leroux-Nicollet
Sep 18, 1998·Brain Research·D J Kennaway, R W Moyer
Aug 13, 2003·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Andrea R TildenKristy T Thurston
Oct 12, 1999·The American Journal of Physiology·S A Ferguson, D J Kennaway

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