Effect of nocturnal blood pressure reduction on circadian fluctuation of mean ocular perfusion pressure: a risk factor for normal tension glaucoma

Investigative Ophthalmology & Visual Science
Jaewan ChoiMichael S Kook

Abstract

To study blood pressure (BP), intraocular pressure (IOP), and mean ocular perfusion pressure (MOPP) in patients with untreated normal tension glaucoma (NTG), and to investigate the relationship between circadian MOPP fluctuation and visual field status at initial presentation. IOP and BP were evaluated in hospital over 24 hours in 132 patients with NTG, with measurements taken every 2 hours between 12 PM and 10 AM the following day, except for the period between 12 and 6 AM, during which measurements were taken every 3 hours. MOPP was calculated from the 24-hour IOP and BP data. Patients were classified into three groups-nondippers, dippers, and overdippers-corresponding to the degree of reduction in their nocturnal mean arterial pressure (MAP) compared with their diurnal MAP. IOP and systemic and ocular hemodynamic parameters were compared among the groups. The correlations between circadian MOPP fluctuation and visual field scores (mean deviation [MD] and corrected pattern standard deviation [CPSD]) at initial presentation were analyzed. Forty-one (31.1%) of the patients with NTGs were classified into the nondipper group, 36 (27.2%) into the dipper group, and 55 (41.7%) into the overdipper group. Marked circadian MOPP fluctua...Continue Reading

Citations

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