PMID: 3122820Dec 1, 1987Paper

Effect of nomegestrol acetate, a new 19-nor-progesterone derivative, on pituitary-ovarian function in women

British Journal of Obstetrics and Gynaecology
B BazinJ Paris

Abstract

After two control cycles, 13 normally menstruating women were treated from day 5 to 25 of the third consecutive cycle with nomegestrol acetate (NOM Ac) 1.25, 2.5 or 5 mg once a day. Plasma oestradiol, FSH and LH concentrations were assayed daily from day 5 to day 25 and plasma progesterone concentrations from day 12 to day 25. Ovulation was inhibited in every woman; LH and progesterone levels were uniformly depressed. With 5 and 2.5 mg/day, plasma oestradiol remained low with high FSH values. With 1.25 mg/day, oestradiol concentrations reached levels similar to those achieved during the control follicular phase, with a concomitant decrease in FSH secretion. These results show an hypothalamic-pituitary effect and suggest an ovarian action, both responsible for a potentially useful contraceptive property.

References

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Aug 1, 1986·British Journal of Obstetrics and Gynaecology·E J ThomasI D Cooke
Jun 1, 1983·Biology of Reproduction·J E Fortune, S E Vincent
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Citations

Sep 7, 2012·Drugs·Lily P H Yang, Greg L Plosker
May 28, 2013·The Journal of Family Planning and Reproductive Health Care·Lee P Shulman
Jun 15, 2011·Contraception·Ronald BurkmanDavid Serfaty
Dec 18, 2012·Women's Health·Sophie Christin-MaitreLéopoldine Bricaire
Feb 22, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Stefano PalombaFulvio Zullo
Aug 11, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Ingrid J M DuijkersTjeerd Korver
Feb 22, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Nathalie Chabbert-BuffetSophie Christin-Maitre
Mar 1, 2012·Maturitas·Xiangyan RuanAlfred O Mueck
Feb 22, 2011·Steroids·Alfred O Mueck, Regine Sitruk-Ware
Oct 12, 2010·Contraception·Regine Sitruk-Ware, Anita Nath
Aug 30, 2014·European Journal of Drug Metabolism and Pharmacokinetics·Qingbiao HuangJim E Riviere
May 18, 2016·Expert Opinion on Drug Metabolism & Toxicology·Giovanni GrandiAngelo Cagnacci
Oct 17, 2018·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano
Mar 1, 1991·British Journal of Obstetrics and Gynaecology·S Bewley
Feb 26, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·E Pucci, F Petraglia
Oct 15, 2014·Clinical Obstetrics and Gynecology·Pamela A Royer, Kirtly P Jones
Dec 1, 1990·Journal of Endocrinological Investigation·J BotellaB Lahlou
Nov 18, 2005·Human Reproduction Update·Regine Sitruk-Ware

Related Concepts

TX 066
Dose-Response Relationship, Drug
Estradiol, (16 alpha,17 beta)-Isomer
Follicle Stimulating Hormone
Luteozyman
Megestrol
Norpregnadienes
Ovary
Ovulation
Pituitary Stalk

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