PMID: 3122820Dec 1, 1987Paper

Effect of nomegestrol acetate, a new 19-nor-progesterone derivative, on pituitary-ovarian function in women

British Journal of Obstetrics and Gynaecology
B BazinJ Paris


After two control cycles, 13 normally menstruating women were treated from day 5 to 25 of the third consecutive cycle with nomegestrol acetate (NOM Ac) 1.25, 2.5 or 5 mg once a day. Plasma oestradiol, FSH and LH concentrations were assayed daily from day 5 to day 25 and plasma progesterone concentrations from day 12 to day 25. Ovulation was inhibited in every woman; LH and progesterone levels were uniformly depressed. With 5 and 2.5 mg/day, plasma oestradiol remained low with high FSH values. With 1.25 mg/day, oestradiol concentrations reached levels similar to those achieved during the control follicular phase, with a concomitant decrease in FSH secretion. These results show an hypothalamic-pituitary effect and suggest an ovarian action, both responsible for a potentially useful contraceptive property.


Jul 1, 1977·Contraception·L ViinikkaR Vihko
Oct 1, 1976·Acta Endocrinologica·L ViinikkaR Vihko
Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·A OrtizD R Mishell
Jul 1, 1975·American Journal of Obstetrics and Gynecology·E FriedrichA E Schindler
Aug 1, 1986·British Journal of Obstetrics and Gynaecology·E J ThomasI D Cooke
Jun 1, 1983·Biology of Reproduction·J E Fortune, S E Vincent
Aug 1, 1980·Molecular and Cellular Endocrinology·J R SchreiberG F Erickson
Mar 1, 1965·Fertility and Sterility·H W RUDELM MAQUEO TOPETE


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Feb 22, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Nathalie Chabbert-BuffetSophie Christin-Maitre
Mar 1, 2012·Maturitas·Xiangyan RuanAlfred O Mueck
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Oct 17, 2018·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano
Mar 1, 1991·British Journal of Obstetrics and Gynaecology·S Bewley
Feb 26, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·E Pucci, F Petraglia
Oct 15, 2014·Clinical Obstetrics and Gynecology·Pamela A Royer, Kirtly P Jones
Dec 1, 1990·Journal of Endocrinological Investigation·J BotellaB Lahlou
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