Effect of non-steroid anti-inflammatory drugs in experimental myocardial infarction in rats

European Journal of Pharmacology
I LepránL Szekeres

Abstract

Four non-steroid anti-inflammatory drugs, sulfinpyrazone, acetylsalicylic acid, sodium salicylate and indomethacin were tested in the acute phase of experimental myocardial infarction in conscious rats. A single oral dose was administered, then 1 h later the occlusion of the left anterior descending coronary artery was made by using a previously implanted silk loop. It was found that each drug markedly increased the survival rate, reduced the occurrence of ventricular fibrillation and tachycardia, and delayed the appearance and shortened the duration of arrhythmias.

References

Jan 1, 1979·Cardiology·A M Lefer, E W Polansky
Oct 1, 1980·The Journal of Pharmacy and Pharmacology·L BrunnerH Brunner
Jan 31, 1980·The New England Journal of Medicine·Anturane Reinfarction Trial Research Group
Dec 1, 1980·Circulation·P C Elwood, P M Sweetnam

Citations

Jan 1, 1986·Agents and Actions·M KoltaiL Szekeres
Jan 22, 1982·European Journal of Pharmacology·I LepránL Szekeres
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
May 1, 1983·Journal of Pharmacological Methods·I LepránL Szekeres
Mar 3, 2004·The Journal of Pharmacology and Experimental Therapeutics·Eric R GrossGarrett J Gross
Mar 1, 1985·Basic Research in Cardiology·I Leprán, A M Lefer
Aug 1, 1982·British Journal of Pharmacology·O FagbemiL Szekeres

Related Concepts

Metazoa
Anti-Inflammatory Agents
Micristin
Sinus Node Artery
Osmosin
Myocardial Infarction
Salicylic Acids
Nu-Sulfinpyrazone
Rats, Laboratory

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.