Effect of non-steroid anti-inflammatory drugs in experimental myocardial infarction in rats

European Journal of Pharmacology
I LepránL Szekeres


Four non-steroid anti-inflammatory drugs, sulfinpyrazone, acetylsalicylic acid, sodium salicylate and indomethacin were tested in the acute phase of experimental myocardial infarction in conscious rats. A single oral dose was administered, then 1 h later the occlusion of the left anterior descending coronary artery was made by using a previously implanted silk loop. It was found that each drug markedly increased the survival rate, reduced the occurrence of ventricular fibrillation and tachycardia, and delayed the appearance and shortened the duration of arrhythmias.


Jan 1, 1979·Cardiology·A M Lefer, E W Polansky
Oct 1, 1980·The Journal of Pharmacy and Pharmacology·L BrunnerH Brunner
Jan 31, 1980·The New England Journal of Medicine·Anturane Reinfarction Trial Research Group
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Jan 1, 1986·Agents and Actions·M KoltaiL Szekeres
Jan 22, 1982·European Journal of Pharmacology·I LepránL Szekeres
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
May 1, 1983·Journal of Pharmacological Methods·I LepránL Szekeres
Mar 3, 2004·The Journal of Pharmacology and Experimental Therapeutics·Eric R GrossGarrett J Gross
Mar 1, 1985·Basic Research in Cardiology·I Leprán, A M Lefer
Aug 1, 1982·British Journal of Pharmacology·O FagbemiL Szekeres

Related Concepts

Anti-Inflammatory Agents
Sinus Node Artery
Myocardial Infarction
Salicylic Acids
Rats, Laboratory

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