May 1, 1975

Effect of noninhalant anesthetics on the conduction of excitation in the ventrolateral columns of the cat spinal cord

Farmakologiia i toksikologiia
O N Chichenkov

Abstract

Acute tests on spinal cats were set up to enquire into the effect produced by sodium oxybutyrate, hexobarbital sodium and viadril used in anesthetic doses on the evoked responses in the ventrolateral columns of the spinal cord following stimulation of the skin and pelvic nerves with single and paired stimuli at an interval of 100 msec. Sodium oxybutyrate forces the amplitude of both the evoked responses after the paired stimulation below the initial level by 40-70 per cent. Hexobarbital sodium and viadril, without changing noticeably the amplitude of the first response, are instrumental in reducing the second one by as much as 30-40 per cent. The responses obtained on stimulation of the pelvic nerve are more sensitive to the test substances than are those evoked by the stimulation of the skin nerve.

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Mentioned in this Paper

Nervousness
Depression, Chemical
Malignant Neoplasm of Spinal Cord
Intravenous Injections
Evipan
Somsanit
Neoplasm of Uncertain or Unknown Behavior of Spinal Cord
Nerve Conduction Function
Anesthesiology
Sodium Hexobarbital

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