Effect of nonylphenol on giant freshwater prawn (Macrobrachium rosenbergii) via oral treatment: toxicity and messenger RNA expression of hemocyte genes

Aquatic Toxicology
Hung-Hung Sung, Yu-Zhi Ye

Abstract

A previous in vitro study has indicated that two alkylphenol ethoxylates (APEs) could potentially damage hemocytes and influence cellular immunity of prawns (Macrobrachium rosenbergii). The aim of this study was to investigate the effects of nonylphenol (NP) on susceptibility to a pathogen and on the mRNA expression of hemocyte genes, including four immune-related genes. NP at different concentrations was fed continuously to prawn (M. rosenbergii) for 1, 3, 6, and 9 days. Challenging prawns with Lactobacillus garvieae resulted in 44-50%, 20-24% and 10-12% mortality were detected after prawns were fed with 100, 10 and 1microNP/prawn for 6 days, respectively. In comparison with control prawns fed with phosphate-buffered solution (PBS), the increase of mRNA levels of four immune-related genes, alpha-2 microglobulin (alpha-2m), antimicrobial peptides (amp), peroxinectin (pon), and prophenoloxidase (propo), was detected on days 1, 3 and 6 after feeding with 100microg/prawn; on day 9, only the mRNA level of amp of the NP-treated group was significantly increased, while that of the remaining groups was not different from that of the control. In addition, two other hemocyte genes were also studied, including a respiration-related gene,...Continue Reading

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Citations

Apr 15, 2014·Ecotoxicology and Environmental Safety·Ryan C GottWilliam O Lamp
Jun 15, 2011·Bulletin of Environmental Contamination and Toxicology·Chang-Lun Liu, Hung-Hung Sung
Oct 28, 2019·Ecotoxicology and Environmental Safety·Ana De la Parra-Guerra, Jesus Olivero-Verbel

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