PMID: 42177Sep 1, 1979

Effect of norepinephrine, GABA and cysteine on the complex of alkaline ribonuclease with its protein inhibitor

Ukrainskiĭ biokhimicheskiĭ zhurnal
G A Nechaeva, E P Shelepina


Norepinephrine GABA, cystein and SH-glutathione evoke a considerable decrease in the activity of alkaline RNase in the postmitochondrial fraction of the rat brain homogenate where the complex of this enzyme with its natural cytoplasmic protein inhibitor is preliminarily disturbed by the addition of pCMB. However these substances have no effect on the activity of alkaline RNase and its cytoplasmic protein inhibitor each taken separately. Evidently, the studied preparations may favour the reduction of the native state of the inactive complex of the enzyme with its inhibitor which was preliminarily disturbed by the pCMB addition.

Related Concepts

Norepinephrine, (+, -)-Isomer
Glutathione Measurement
Plasma Protein Binding Capacity
Alkaline Ribonuclease
Norepinephrine Measurement
Pancreatic ribonuclease
Rat Brain

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