PMID: 2108105Mar 1, 1990Paper

Effect of normobaric oxygen on tumor radiosensitivity: fractionated studies

International Journal of Radiation Oncology, Biology, Physics
A RojasK Reghebi

Abstract

The sensitizing ability of 100% normobaric oxygen was investigated in a mouse mammary carcinoma (CaNT) using a variety of fractionated regimens. Both regrowth delay and local control were used as assays of tumor response. With both assays, there was a similar and significant increase in radiosensitivity for all fractionated schedules. Enhancement ratios ranged from 1.24 to 1.45, the highest increase being observed with a 30 fraction schedule given in an overall time of 6 weeks. Thus, in CaNT tumors normobaric oxygen is a far more efficient radiosensitizer in fractionated treatments than the oxygen-mimetic compound misonidazole; an oxygen effect being observed at doses per fraction as low as 1.8 Gy. These results suggest strongly that normobaric gases could play an important role in the clinical management of tumors where hypoxia may limit the outcome of radiotherapy.

References

May 1, 1989·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S A HillJ Denekamp
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·R P Hill
Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J OvergaardM Hjelm Hansen
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M V WilliamsJ F Fowler
Oct 1, 1963·The British Journal of Radiology·L A DUSAULT
Dec 1, 1964·The Journal of Physiology·L H GRAY, J M STEADMAN

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Citations

Apr 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A RojasJ Denekamp
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·L E Gerweck, F W Hetzel
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·A RojasH Johns
Apr 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H P Beck-BornholdtH Willers
Aug 6, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P J HoskinH Baddeley
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·K A HartmannP Sminia
Sep 1, 1991·International Journal of Radiation Biology·H Johns, M C Joiner
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·C GrauJ Overgaard
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·A M RojasP R Fiat
Oct 1, 1993·Cancer Treatment Reviews·S M SagarJ E Aldrich
Apr 6, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael R Horsman, Jens Overgaard
Jun 20, 1998·Seminars in Radiation Oncology·S P RobinsonJ R Griffiths
Jun 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A RojasJ Denekamp
Dec 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DischeE Aird
Jan 1, 1992·The British Journal of Radiology·S DischeB D Michael
Oct 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E KjellenA Rojas
Aug 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K OnoM Abe
Apr 25, 2020·Experimental Biology and Medicine·Sei W KimSang H Lee
Oct 1, 1994·Journal of Surgical Oncology·L HewR Bell
Oct 1, 1991·Journal of Photochemistry and Photobiology. B, Biology·I Freitas, G F Baronzio

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