Effect of novel blend nanofibrous scaffolds on diabetic wounds healing

IET Nanobiotechnology
A Gholipour-KananiS Rabbani

Abstract

Chitosan-poly (vinyl alcohol) (Cs: PVA) (2:3) and poly (caprolactone)-chitosan-poly (vinyl alcohol) (PCL: Cs: PVA) (2:1:1.5) nanofibrous blend scaffolds were fabricated using the electrospinning technique in the authors' previous studies. The results of the previous studies confirmed the high biological properties of the scaffolds and their ability in healing of burn and excision wounds on rat model. In the present study, the biological scaffolds were applied on diabetic dorsum skin wounds and diabetic foot wound on rat models (n = 16). Macroscopic and microscopic investigations were carried out using digital images and haematoxylin and eosin (H&E) staining respectively, to measure the wound areas and to track wound healing rate. It was found that at all time points the areas of wounds treated with nanofibrous scaffolds were smaller compared with the controls. Pathological results showed much better healing efficacy for the test samples compared with the control ones. Pathological investigations proved the presence of more pronounced granulation tissues in the scaffold-treated wounds compared with the control ones. At 20 days post excision, the scaffold-treated groups achieved complete repair. The results indicated that Cs: PVA...Continue Reading

References

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Citations

Aug 23, 2017·Biomaterials Science·Lisa N Kasiewicz, Kathryn A Whitehead
Jun 4, 2020·Pharmaceutics·Atanu Naskar, Kwang-Sun Kim
Aug 30, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hong Cai, Guichen Li
Jul 10, 2019·Materials·Mara Madalina MihaiAlina Maria Holban
Oct 13, 2020·Biotechnology and Applied Biochemistry·Hosna ZareMojtaba Sankian
May 6, 2021·International Journal of Molecular Sciences·Kaushita BanerjeeHarishkumar Madhyastha
Oct 14, 2021·Journal of Nanobiotechnology·Hassan MalekiFarshad Sharifi

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