Effect of nucleus pulposus on the neural activity of dorsal root ganglion

Spine
Tsuneo TakebayashiC Chen

Abstract

This study was designed to investigate, using neurophysiologic techniques in an in vivo rat model, the effect of application of nucleus pulposus to the nerve root on the neural activity of the dorsal root ganglion and the corresponding receptive fields. To assess a further role of the dorsal root ganglion in mechanisms of radicular pain in lumbar disc herniation. It has been suggested that the epidural application of autologous nucleus pulposus without mechanical compression causes nerve root inflammation and related radicular pain in lumbar disc herniation. Concerning the dorsal root ganglion, its mechanical hypersensitivity and potential for generating ectopic discharges have been reported. However, the effect of autologous nucleus pulposus on the dorsal root ganglion is uncertain. In adult Sprague-Dawley rats spontaneous neural activity was recorded from the surgically exposed L5 dorsal root using electrophysiologic techniques, and the mechanosensitivity of L5 dorsal root ganglia and corresponding receptive fields on the hind paw were measured using calibrated nylon filaments. Autologous nucleus pulposus from the tail or fat was implanted at the L5 nerve root. Neural activity was monitored for 6 hours. Spontaneous neural act...Continue Reading

References

Nov 14, 1997·Journal of Neurophysiology·J M ZhangR H Lamotte

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Citations

Jun 21, 2006·Der Radiologe·T WaggershauserM Reiser
Aug 4, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Srinivasu KallakuriJohn M Cavanaugh
Feb 14, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·A Cüneyt OzaktayJames N Weinstein
Mar 25, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Munetaka SuzukiSeiji Ohtori
Jan 24, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·E NilssonI Hammar
Mar 8, 2005·The Spine Journal : Official Journal of the North American Spine Society·Robert F McLainNagy A Mekhail
Dec 7, 2006·Pain Practice : the Official Journal of World Institute of Pain·Phillip S SizerOmer Matthijs
Feb 5, 2008·Spine·Helena Brisby, Ingela Hammar
Nov 21, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jan FritzPhilippe L Pereira
Jan 30, 2013·Journal of Forensic and Legal Medicine·Charles G Davis
May 19, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shigeo TakahataToshihiko Yamashita
Apr 5, 2008·Clinics in Geriatric Medicine·William F LavelleHoward S Smith
Dec 7, 2007·Anesthesiology Clinics·William LavelleElizabeth Demers Lavelle
Feb 27, 2007·The Medical Clinics of North America·William LavelleElizabeth Demers Lavelle
Dec 5, 2006·Journal of Manipulative and Physiological Therapeutics·Gregory CramerJoel Pickar
Mar 7, 2008·European Journal of Pain : EJP·Jaro KarppinenMinna Männikkö
Feb 22, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zhong-Min WuShu-Cai Ling
May 2, 2014·The Journal of Small Animal Practice·A E Mouradian-DarbyJ M Levine
Oct 27, 2004·The Journal of Pain : Official Journal of the American Pain Society·Seiji OhtoriHideshige Moriya
Aug 14, 2003·The Orthopedic Clinics of North America·Helena Brisby
Oct 29, 2013·Diagnostic and Interventional Imaging·B DallaudièreE Schouman-Claeys
Apr 22, 2015·Journal of Bodywork and Movement Therapies·Michalis A EfstathiouGiannis Giakas
Apr 24, 2015·AJR. American Journal of Roentgenology·Eugene JoeHeung Sik Kang
May 4, 2002·Best Practice & Research. Clinical Rheumatology·Bruce L Kidd, Peter M Richardson
Sep 12, 2006·Pain·Baogan PengXiaoning Wang
Jun 14, 2016·International Journal of Inflammation·Aurora MoenTorsten Gordh

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