PMID: 1211997Aug 1, 1975Paper

Effect of nutrition, diet and suture material on long term wound healing

Annals of Surgery
W J TempleJ S Crispin

Abstract

Although it is known that malnutrition hinders early wound healing, it has not been determined whether this occurs because of formation of a poor scar or a slow rate of normal healing; the ultimate fate of the malnourished wound is unknown. Malnutrition was produced in rats by short gut syndrome. Elemental diet was compared to rat chow and silk was compared with polyglycolic acid suture. Nutritional deficiency was seen in short gut rats for two weeks postoperatively. Thereafter adaptation allowed partial recovery, but relative deficiency persisted. Morbidity and mortality of short gut rats doubled that of controls and all wound complications were limited to this group, occurring within the first two weeks. Malnourished animals surviving for 60 days had wound strength equal to the control rats as determined by gut anastomosis bursting strength, skin wound breaking strength and wound hydroxyproline content. Neither diet nor suture material altered ultimate wound strength. Improved nutrition allowed more animals and wound to survive, but ultimate healing survivors was indistinguishable from that of normal controls. Thus early weakness probably results from slow healing rather than formation of poor scar. Nutrition plays an importa...Continue Reading

References

Nov 1, 1974·Annals of Surgery·J M DalyS J Dudrick
Feb 1, 1965·Annals of Surgery·S M LEVENSONH ROSEN
Jun 1, 1965·The Journal of Surgical Research·D T CRAWFORD, A S KETCHAM

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Citations

Dec 1, 1983·Annals of Surgery·P M StarkerJ M Kinney
Jan 8, 2000·Plastic and Reconstructive Surgery·R J RohrichP C Hobar
Jun 1, 1990·The Australian and New Zealand Journal of Surgery·R McCauleyR McCulloch
Jan 9, 2010·International Journal of Molecular Sciences·Anna V PiterinaTim M McGloughlin
Feb 1, 1989·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S T FanY P Chan
Apr 28, 2006·Clinics in Plastic Surgery·James B Lowe
Jan 18, 2017·Journal of Dental Research, Dental Clinics, Dental Prospects·Javad YazdaniYousef Kananizadeh
Jan 1, 1984·Die Nahrung·W Müller-BeuthowF K Grütte
Oct 1, 1994·Journal of the American Geriatrics Society·D A BucklerJ S Goodwin
Jul 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·J E Albina
Oct 1, 1979·The Journal of Surgical Research·D F DevereuxM F Brennan
Oct 1, 1985·Current Problems in Surgery·J J Reilly, A L Gerhardt

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