PMID: 2484430Jan 1, 1989Paper

Effect of nutritional copper deficiency on carrageenin edema in the rat. A quantitative study

Biological Trace Element Research
V KishoreL Fourcade

Abstract

The effects of nutritional copper deficiency on carrageenin edema in the rat were investigated with emphasis on studying the correlation between the degree of copper deficiency and the degree of edema. Carrageenin paw edema in both copper-sufficient and copper-deficient groups of rats was compared after either 20, 40, or 60 d on respective diets. The degree of copper deficiency was quantitated by analyzing total copper concentrations in a number of tissues. Other copper dependent parameters were also determined. Results indicated that: (1) although copper sufficient rats showed relatively little change in the degree of edema, copper-deficient rats showed a steady and significant increase in edema from d 20 to 40 to 60; (2) paw edema in copper-deficient animals was highly and negatively correlated to the concentrations of copper in the liver; the correlation with liver Cu,Zn-superoxide dismutase activity, however, was inconsistent; (3) paw edema was not correlated either to copper concentration in tissues other than liver or to plasma ceruloplasmin activity; and (4) aggravation of carrageenin edema in copper-deficient animals seemed to be mediated via an as yet unknown secondary effect of copper deficiency.

References

Dec 1, 1979·Agents and Actions·R MilaninoG P Velo
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Jan 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·M FieldsS Reiser
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Apr 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·M FieldsJ C Smith

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Citations

May 1, 1990·Biological Trace Element Research·V KishoreL Fourcade
Feb 1, 1994·Biological Trace Element Research·A Lopez-AnayaV Kishore
Jan 5, 2000·BioFactors·J T Saari, D A Schuschke
Aug 1, 1994·Agents and Actions·D A SchuschkeF N Miller
Jan 25, 2007·Reviews on Environmental Health·Roberto Milanino, Virginia Buchner
Jan 24, 1998·The Journal of Nutrition·D A Schuschke

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