Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials

Nutrients
Xiao Li ShenGuohua Zhao

Abstract

Many individual studies on oat β-glucan (OBG) confirmed its functionality in improving type 2 diabetes mellitus (T2DM), but disagreements were identified among those results. To derive a pooled estimate of these results, relevant articles, published before 5 September 2015, were collected from four electronic databases (Pubmed, Cochrane Library, Scopus, and Web of Science) and subjected to meta-analysis in the present work. In total, four articles, dealing with 350 T2DM patients combined, met the inclusion criteria. Compared to control, T2DM patients administrated OBG from 2.5 to 3.5 g/day for 3 to 8 weeks presented significantly lowered concentrations in fasting plasma glucose (FPG) by -0.52 (95% CI: -0.94, -0.10) mmol/L (p = 0.01) and glycosylated hemoglobin (HbA1c) by -0.21% (95% CI: -0.40, -0.02) (p = 0.03). However, OBG intake did not significantly lower the fasting plasma insulin (FPI) concentration. In conclusion, mediate-term OBG intake (3-8 weeks) favored the glycaemic control of T2DM patients but did not improve their insulin sensitivity. Regrettably, data upon the effects of long-term OBG intake on glycaemic control and insulin sensitivity were scarce, which is of much importance and should be addressed in future res...Continue Reading

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Citations

Mar 10, 2017·Redox Report : Communications in Free Radical Research·Noori Al-WailiKhelod Salom
Feb 27, 2019·Critical Reviews in Food Science and Nutrition·Weijing WuZaigui Li
Sep 11, 2019·Nutrition and Health·Maximilian Andreas Storz, Onno Küster
Apr 14, 2019·Wiener klinische Wochenschrift·Karin SchindlerBernhard Ludvik
Oct 9, 2020·Nutrients·Nirmala Prasadi V P, Iris J Joye
Sep 25, 2020·Diabetes Research and Clinical Practice·Rukiye BozbulutPeyami Cinaz
Feb 21, 2021·European Journal of Clinical Nutrition·Andreea ZurbauThomas M S Wolever
Jul 30, 2021·Nutrición hospitalaria·Guillermo Mena SánchezSuelen Souza
Jul 7, 2017·Journal of Agricultural and Food Chemistry·Min LiMario G Ferruzzi

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