PMID: 11328671May 1, 2001Paper

Effect of obesity and troglitazone on expression of two glutathione peroxidases: cellular and extracellular types in serum, kidney and adipose tissue

Free Radical Research
K AsayamaS Nakazawa

Abstract

To determine the effect of obesity on expression of cellular- (C-) and extracellular (EC-) glutathione peroxidase (GPX) in serum, kidney and adipose tissue, we measured GPX in serum, kidneys and adipose tissue of the obese Otsuka-Long-Evans-Tokushima Fatty (OLETF) rat and its lean counterpart (LETO). We also investigated the effect of troglitazone. Five each of OLETF and LETO rats were fed diet with or without 0.2% troglitazone for 10 days. Final body weight, kidney weight, blood glucose and serum tumor necrosis factor-alpha (TNF-alpha) level were higher in OLETF rats than in LETO rats. Serum and kidney GPX activities were higher, but adipose tissue GPX activity was lower, in OLETF rats than in LETO rats. Troglitazone treatment decreased adipose tissue GPX activity and abolished overproduction of TNF-alpha in OLETF rats. Immunoblot analysis, for the first time, revealed that both obesity and troglitazone suppressed the protein signals for C-GPX and EC-GPX in adipose tissue. Serum protein carbonyl groups were increased in OLETF rats and troglitazone completely blocked this increase. Increased serum GPX activity in obese rat was due to the increased secretion of EC-GPX from the kidney. Troglitazone protected against the enhanced ...Continue Reading

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Citations

May 4, 2007·The British Journal of Nutrition·Chin-Lin Hsu, Gow-Chin Yen
Jul 23, 2008·PPAR Research·Roberto ScatenaBruno Giardina
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Seyed Hamid KamaliSeyed Ali Kamali
Jul 20, 2005·The Journal of Pediatrics·Claudia MandatoPietro Vajro
Nov 16, 2010·Human & Experimental Toxicology·Uma BhandariBibhu Prasad Panda
Feb 25, 2014·International Journal of Molecular Sciences·Azahara I RupérezConcepción M Aguilera
Jun 1, 2006·Cell and Tissue Research·Tadashi YamasakiShin'ichi Ito
Oct 19, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A OzaydinG Sultuybek
Apr 30, 2020·Biomolecules·Alexey A TinkovAnatoly V Skalny
Jun 5, 2013·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·Anna Vallverdú-QueraltRosa M Lamuela-Raventós
Dec 13, 2017·Molecular Genetics and Genomics : MGG·Ning LiZhanjiang Liu
Jan 27, 2021·Journal of Personalized Medicine·Olga I KiselevaElena A Ponomarenko
Aug 10, 2007·Journal of Agricultural and Food Chemistry·Chin-Lin HsuGow-Chin Yen

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