Effect of obesity on biodistribution of nanoparticles

Journal of Controlled Release : Official Journal of the Controlled Release Society
Claudiana de Jesus FelisminoRalph Santos-Oliveira

Abstract

Nanoparticles have specific features (lipophilicity, surface charge, composition and size). Studies regarding the biological behavior of nanoparticles in diseases such diabetics and obesity are scarce. Here, we evaluated two nanoparticles: magnetic core mesoporous silica (MSN) (58 nm) and polycaprolactone (PCL) nanoparticle (280 nm) in obese mice. Changes in the biodistribution were observed, especially considering the mononuclear phagocyte system (MPS), and the visceral fat tissue. Nonetheless, our data corroborates the influence of size in the biodistribution in obese animals, supporting that smaller nanoparticles, may show a higher tissue deposition at spleen, due the associated splenomegaly and the complications arising from this state. Finally, our study demonstrated that, in obesity, probably due the low-grade inflammatory state associated with metabolic syndrome a difference in accumulation of nanoparticles was found, with profound impact in the tissue deposition of nanoparticles.

Citations

Nov 20, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Filipe Leal PortilhoRalph Santos-Oliveira
Apr 3, 2019·Advanced Healthcare Materials·Yung-Hao TsouXiaoyang Xu
Jan 8, 2020·International Journal of Molecular Sciences·Edward Helal-NetoRalph Santos-Oliveira
Oct 11, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Estefany I Medina-ReyesJosé Pedraza-Chaverri
Aug 11, 2020·Acta Biomaterialia·Mengmeng LongZhongping Chen

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