Effect of obesity on high-density lipoprotein metabolism

Obesity
Shirya Rashid, Jacques Genest

Abstract

Reduced levels of high-density lipoproteins (HDL) in non-obese and obese states are associated with increased risk for the development of coronary artery disease. Therefore, it is imperative to determine the mechanisms responsible for reduced HDL in obese states and, conversely, to examine therapies aimed at increasing HDL levels in these individuals. This paper examines the multiple causes for reduced HDL in obese states and the effect of exercise and diet--two non-pharmacologic therapies--on HDL metabolism in humans. In general, the concentration of HDL-cholesterol is adversely altered in obesity, with HDL-cholesterol levels associated with both the degree and distribution of obesity. More specifically, intra-abdominal visceral fat deposition is an important negative correlate of HDL-cholesterol. The specific subfractions of HDL that are altered in obese states include the HDL2, apolipoprotein A-I, and pre-beta1 subfractions. Decreased HDL levels in obesity have been attributed to both an enhancement in the uptake of HDL2 by adipocytes and an increase in the catabolism of apolipoprotein A-I on HDL particles. In addition, there is a decrease in the conversion of the pre-beta1 subfraction, the initial acceptor of cholesterol fr...Continue Reading

References

Feb 1, 1976·The American Journal of Clinical Nutrition·S LewisM B Pereira
Mar 1, 1992·Metabolism: Clinical and Experimental·S W CoppackT D Hockaday
Jan 1, 1992·The American Journal of Clinical Nutrition·J B HauptmanD Hartmann
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Aug 1, 1990·The Journal of Clinical Investigation·A R Tall
Apr 1, 1990·Circulation·P D Thompson
May 1, 1990·Metabolism: Clinical and Experimental·P T Williams
Feb 1, 1989·The Journal of Clinical Investigation·B Kiens, H Lithell
Jun 1, 1989·Annals of Internal Medicine·A N PeirisA H Kissebah
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Mar 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Jun 1, 1985·The Journal of Clinical Investigation·B S FongR E Gregg
Sep 1, 1988·Atherosclerosis·M C BertièreA Girard-Globa
Nov 12, 1987·The New England Journal of Medicine·B M Rifkind
Mar 1, 1985·Metabolism: Clinical and Experimental·G SopkoI Frantz
Sep 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J F Oram
Mar 1, 1983·Annals of Internal Medicine·E ReisinH M Batson
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J R PatschA M Gotto
Aug 18, 1983·The New England Journal of Medicine·J J MaciejkoS J Mao
Dec 1, 1984·The Journal of Clinical Investigation·J R PatschG Bengtsson-Olivecrona
Mar 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R N Wolf, S M Grundy
May 1, 1984·Metabolism: Clinical and Experimental·M A KantorP D Thompson
Aug 24, 1984·JAMA : the Journal of the American Medical Association·P N HerbertP D Thompson
Dec 1, 1981·European Journal of Clinical Investigation·R SörbrisP Nilsson-Ehle
May 21, 1982·JAMA : the Journal of the American Medical Association·P T WilliamsK Vranizan
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A H KissebahP W Adams
May 1, 1981·The Journal of Clinical Investigation·R S Schwartz, J D Brunzell
Oct 1, 1980·Metabolism: Clinical and Experimental·R J GarrisonP M McNamara

❮ Previous
Next ❯

Citations

Aug 19, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Patricia K Doyle-BakerTak Fung
Apr 15, 2011·Cholesterol·Catherine Rolland, Iain Broom
Oct 13, 2011·Lipids in Health and Disease·Hao Wang, Dao-Quan Peng
Apr 8, 2010·Journal of Lipid Research·Menno VergeerJan Albert Kuivenhoven
Jul 23, 2014·Clinical and Experimental Hypertension : CHE·Huili ChenZheng Wan
Dec 20, 2012·Climacteric : the Journal of the International Menopause Society·A Di BlasioG Napolitano
Feb 17, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katsuyasu KoudaMasayuki Iki
Jul 31, 2013·Journal of Clinical Lipidology·Harold E BaysVarman T Samuel
Dec 8, 2015·The Journal of Clinical Investigation·Chang Yeop HanAlan Chait
Mar 17, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Laura López-SimónCarmen Garcés
Nov 6, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Yan XiaMu-Ping Nieh
Jun 25, 2008·The Journal of Animal Ecology·Jordi Moya-LarañoCarmen Fernández-Montraveta
Feb 22, 2012·Journal of Food Science·Young-Mee ChungChi Hye Park
Dec 2, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·M Elizabeth TejeroA G Comuzzie
Apr 5, 2016·Food & Function·Kiara ThompsonAbishek Bommannan Santhakumar
May 21, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Pedro BorgesLuísa M P Valente
Dec 31, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ali AminianPhilip R Schauer
Dec 27, 2008·Atherosclerosis·E KassiA Dionyssiou-Asteriou
Dec 9, 2014·Biochemical and Biophysical Research Communications·Whasun LimGwonhwa Song
Oct 31, 2016·Advanced Drug Delivery Reviews·Zhong-Cheng MoGuang-Hui Yi
Aug 26, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Yan XiaMu-Ping Nieh
Oct 7, 2016·European Journal of Epidemiology·Takumi HirataUNKNOWN Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group
Oct 23, 2015·BMC Public Health·Anselmo Mc DonaldClara Cruz
Feb 6, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joe Antony JacobBaoan Chen
Mar 23, 2017·British Journal of Pharmacology·Fatima IqbalDemidmaa Tuvdendorj
Jul 5, 2017·Journal of Food Science·Hsueh-Chin ChaoMing-Chang Wu
Oct 6, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S BollepalliM Ollikainen
Aug 4, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Swarup A V ShahTester F Ashavaid
Mar 23, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Anouk M la RoseMarit Westerterp
Jan 5, 2014·Circulation Research·Federico OldoniJan Albert Kuivenhoven
Feb 9, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·J A GriegerC T Roberts
Sep 9, 2011·Current Atherosclerosis Reports·Patty W Siri-Tarino
Jun 23, 2020·PloS One·Stanisław GłuszekEdyta Suliga

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