Effect of obesity on oxygen uptake and cardiovascular dynamics during whole-body and leg exercise in adult males and females

Physiological Reports
Simon GreenMikel Egaña

Abstract

Obesity has been associated with a slowing of V˙O2 dynamics in children and adolescents, but this problem has not been studied in adults. Cardiovascular mechanisms underlying this effect are not clear. In this study, 48 adults (18 males, 30 females) grouped according to body mass index (BMI) (lean < 25 kg·m-2 , overweight = 25-29.9 kg·m-2 , obese ≥30 kg·m-2 ) provided a fasting blood sample, completed a maximal graded exercise test and six bouts of submaximal exercise on a cycle ergometer, and performed two protocols of calf exercise. Dynamic response characteristics of V˙O2 and leg vascular conductance (LVC) were assessed during cycling (80% ventilatory threshold) and calf exercise (30% MVC), respectively. Dynamic responses of cardiac output, mean arterial pressure and total systemic vascular conductance were also assessed during cycling based on measurements at 30 and 240 sec. The time constant of the second phase of the V˙O2 response was significantly greater in obese than lean subjects (39.4 (9.2) vs. 29.1 (7.6) sec); whereas dynamic responses of cardiac output and systemic vascular conductance were not affected by BMI. For calf exercise, the time constant of the second growth phase of LVC was slowed significantly in obese ...Continue Reading

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Citations

Oct 30, 2018·The Proceedings of the Nutrition Society·Keith N Frayn
Mar 7, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Simon GreenMikel Egaña
Jul 30, 2019·Journal of Sports Medicine·Sara KindThomas Dieterle
May 1, 2021·International Journal of Environmental Research and Public Health·Maria RadziejowskaMichał Zych

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

Systat
TableCurve
SPSS

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