Effect of obesity on the association between MYL2 (rs3782889) and high-density lipoprotein cholesterol among Korean men

Journal of Human Genetics
Eo Rin ChoJae Woong Sull

Abstract

High-density lipoprotein (HDL) cholesterol levels are associated with a decreased risk of coronary artery disease. Several genome-wide association studies that have examined HDL cholesterol levels have implicated myosin light chain 2 regulatory cardiac slow (MYL2) as a possible causal factor. Herein, the association between the rs3782889 single-nucleotide polymorphism (SNP) in the MYL2 gene and HDL cholesterol levels was tested in the Korean population. A total of 4294 individuals were included in a replication study with MYL2 SNP rs3782889. SNP rs3782889 in the MYL2 gene was associated with mean HDL cholesterol level (effect per allele, -1.055 mg dl(-1), P=0.0005). Subjects with the CT/CC genotype had a 1.43-fold (range 1.19-1.73-fold) higher risk of an abnormal HDL cholesterol level (<40 mg dl(-1)) than subjects with the TT genotype. When analyzed by sex, the MYL2 association was stronger in men than that in women. When analyzed by body mass index (BMI), the MYL2 association was much stronger in male subjects with BMI ⩾26.44 kg m(-2) (odds ratio (OR)=2.68; 95% confidence interval (CI)=1.87-3.84; P<0.0001) than that in male subjects with BMI <26.44 kg m(-2). When compared with subjects having the TT genotype and BMI <26.44 kg ...Continue Reading

References

Jun 17, 2004·Circulation·Gerd Assmann, Antonio M Gotto
Apr 23, 2008·Current Protocols in Human Genetics·Lester HuiKoustubh Ranade
Sep 3, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Tamio TeramotoUNKNOWN MEGA Study Group
Mar 17, 2012·European Journal of Medical Genetics·O CampuzanoR Brugada
Jun 13, 2012·Molecular and Cellular Biology·Jose T ThaiparambilAdam I Marcus
Feb 1, 2013·Journal of Human Genetics·Ji-Young LeeJong-Young Lee
Feb 1, 2013·Brain : a Journal of Neurology·Marian A J WetermanFrank Baas
Apr 10, 2013·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·P A van der ZwaagJ P van Tintelen
Oct 22, 2013·Human Genetics·Seong Gu HeoJi Wan Park
Oct 27, 2015·European Heart Journal·Godelieve R F ClaesArthur van den Wijngaard

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