PMID: 6962666Jan 1, 1982Paper

Effect of occlusal disorder on the gingiva in rats with experimental arteriosclerosis. Enzyme histochemical and biochemical study

Acta Odontologica Scandinavica
V Lassila

Abstract

This histochemical study showed that experimentally arteriosclerotic rats, subjected to an occlusal stress of six weeks' duration, showed an inflammation-related increase of chloride-activated arginine aminopeptidase and acid phosphatase activity in the basal cells of the gingival epithelium. The activity of chloride-activated arginine aminopeptidase and acid and alkaline phosphatase in the gingival connective tissue was slight and suggestive of chronic inflammation. Biochemical comparison of gingival specimens from the stressed and unstressed sides of the jaw in the experimental animals failed to reveal any difference in the rate of N-L-arginyl-2-naphthylamide hydrolysis induced by the C1-ion in connection with occlusal disorder. On the other hand, the mean value of the enzyme activity was lower in the experimental animals than the controls (p less than 0.5). The difference was assumed to be associated with degenerative tissue changes. The hydrolysis of p-nitrophenyl phosphate at acidic and alkaline pH in the gingiva was higher in the experimental animals than in the controls, and in the alkaline pH range the difference between the mean values was statistically significant (p less than 0.01). This finding, which may be associa...Continue Reading

References

Mar 30, 1978·Biochemical and Biophysical Research Communications·M KnuuttilaK K Mäkinen
Apr 15, 1977·FEBS Letters·E SöderlingK K Mäkinen
Jun 1, 1975·Biochemical Medicine·K K MäkinenS Luoma
Mar 1, 1972·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K K Mäkinen, K U Paunio
Jan 1, 1973·Journal of Periodontal Research·H PlenkR Waechter
Jun 1, 1969·Journal of Periodontology·M R Wirthlin, P A Ratcliff
Jan 1, 1982·Acta Odontologica Scandinavica·V Lassila, K K Koivumaa
Jun 1, 1965·Experimental and Molecular Pathology·J RAEKALLIO

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