PMID: 9558301May 19, 1998Paper

Effect of occlusion on cell proliferation during epidermal healing

Journal of Cutaneous Medicine and Surgery
R LevineP M Mertz

Abstract

Occlusive dressings influence epithelization of superficial wounds by some unknown mechanism(s). The effects of occlusion on epidermal cell proliferation in two types of wounds were examined. Partial-thickness wounds and tape-stripped skin wounds were compared. An immunohistochemical technique, employing PC10 - a monoclonal antibody against proliferating cell nuclear antigen (PCNA) - was applied to formalin-fixed, paraffin-embedded porcine tissue sections. The number of PC10-positive cells was low during the migratory phase, then increased to a peak of proliferation 2 to 3 days after resurfacing. An overall increased proliferative response (mean = 21%) was seen in occluded compared to control partial-thickness wounds (day 10 postoperatively); an opposite effect of occlusion on epidermal proliferation was seen in tape-stripped skin. Occlusion decreased the proliferative response (mean = 42%) compared to air-exposure. Occlusion increased epidermal cell proliferation in wounds (where the entire surface epithelium and papillary dermis was removed), whereas an opposite effect was seen in tape-stripped skin from which only the stratum corneum had been removed.

References

Jan 1, 1992·The Journal of Investigative Dermatology·Y SarretE J O'Keefe
Apr 2, 1987·Nature·R BravoH Macdonald-Bravo
Aug 1, 1983·The Journal of Surgical Research·O M AlvarezW H Eaglstein
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M MarikovskyM Klagsbrun
Aug 1, 1962·Biological Reviews of the Cambridge Philosophical Society·W S BULLOUGH
Jun 1, 1963·Experimental Cell Research·E A HELL, C N CRUICKSHANK
May 1, 1971·The Journal of Cell Biology·W S Krawczyk

❮ Previous
Next ❯

Citations

Mar 17, 2010·Archives of Dermatological Research·Alexandra L Varol, Chris D Anderson
Oct 18, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M L Bowen, M Selinger
Jan 13, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M M ChristianR L Moy
Sep 11, 2003·Journal of Wound Care·M S AgrenJ Rygaard
May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T P SullivanP Mertz
Jul 11, 2007·Advances in Skin & Wound Care·Asha R PatelRobert S Kirsner
Jan 8, 2009·International Journal of Dermatology·Asha R PatelRobert S Kirsner
Jun 10, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·T OnouyeR Moy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.