Effect of Octenisept antiseptic on bioburden of neoplastic ulcers in patients with advanced cancer

Journal of Wound Care
M SopataE Tomaszewska

Abstract

To assess the effect of octenidine dihydrochloride (Octenisept, Schülke & Mayr) on the clinical condition and bacterial flora in neoplastic ulcers. Twenty-one patients with advanced cancer and neoplastic ulcers were included in the study. Octenisept-moistened gauze dressings were applied to the ulcers three times daily. The clinical and bacteriological status of the wounds were assessed at baseline and after three weeks of treatment. Thirty-three bacterial strains were cultured at baseline. After three weeks of treatment, the tests were repeated on 16 patients. Clinical observations confirmed an improvement in the clinical condition of the ulcers, characterised by a reduction in necrosis, exudate levels, erythema and oedema. According to the bacteriological assessment, Staphylococcus aureus, Staphylococcus epidermidis and Proteus mirabilis were eradicated from the wounds. Enterococcus faecalis persisted in two patients, Escherichia coli in one patient and Pseudomonas aeruginosa in another patient. Octenispet was an effective antimicrobial: Staphylococcus aureus and Proteus mirabilis were eradicated in all ulcers. After three weeks of treatment, none of the ulcers developed an infection and there was an improvement in their clin...Continue Reading

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Citations

Feb 21, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Trevis CalowHauke Schumann
Jun 16, 2017·Journal of Oncology Practice·Chadi Nabhan, Bruce A Feinberg
Sep 8, 2010·Annals of the Royal College of Surgeons of England·David LeaperMartin Kiernan
Oct 25, 2008·Journal of Wound Care·M SopataE Tomaszewska

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