Effect of octreotide on mouth-to-caecum transit time in healthy subjects and in the irritable bowel syndrome

Alimentary Pharmacology & Therapeutics
L J O'DonnellM J Farthing

Abstract

The effect of a single subcutaneous injection of octreotide (50 micrograms) on mouth-to-caecum transit time was determined in patients with the irritable bowel syndrome who complained of bowel frequency, and in healthy volunteers. The assessment of mouth-to-caecum transit time was performed by monitoring breath hydrogen concentration and noting a sustained 10 p.p.m. rise after ingestion of lactulose 40 ml. Measurements were performed fasting, and on a separate day, after a standard breakfast which included 40 ml lactulose. The studies were performed double-blind in a pre-determined random order. Octreotide prolonged mouth-to-caecum transit time in irritable bowel syndrome patients and healthy subjects by factors of 2.4 and 2.6 after lactulose when fasting, respectively, and by factors of 2.8 and 2.6 after the breakfast which contained lactulose. The upper gastrointestinal transit rate was similar in irritable bowel syndrome patients and healthy controls.

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Citations

Dec 1, 1991·Alimentary Pharmacology & Therapeutics·L J O'DonnellM J Farthing
May 26, 2001·The American Journal of Gastroenterology·V NehraD G Kelly
Sep 13, 2001·Alimentary Pharmacology & Therapeutics·S P PereiraR H Dowling
Jan 5, 2002·Expert Opinion on Investigational Drugs·A FarhadiA Keshavarzian
Jan 11, 2003·American Journal of Therapeutics·Amir GarakaniPrakash S Masand
Feb 27, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Van Op den BoschJ-P Timmermans
Jul 21, 2000·Alimentary Pharmacology & Therapeutics·R H Dowling
Nov 30, 2000·Current Treatment Options in Gastroenterology·E E Soffer
May 8, 2008·World Journal of Gastroenterology : WJG·Christopher W Hammerle, Christina M Surawicz
Aug 1, 1991·Alimentary Pharmacology & Therapeutics·A K Burroughs, P A McCormick
Oct 14, 2005·Obesity Research·Filippo CremoniniDuane Burton
Mar 9, 2017·Scandinavian Journal of Gastroenterology·Laura MartelliEdouard Louis
Sep 13, 2019·International Journal of Molecular Sciences·Slawomir Gonkowski, Liliana Rytel
Dec 21, 2004·Alimentary Pharmacology & Therapeutics·D Lesbros-PantoflickovaA L Blum
Nov 30, 2000·Current Treatment Options in Gastroenterology·E M Quigley
Oct 19, 2001·Gastroenterology·M J VeyseyR H Dowling
Aug 12, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Camilleri, V Andresen

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