Effect of oestriol succinate on serum lipids

Maturitas
S SaarikoskiP Pystynen

Abstract

The series comprises 70 women with climacteric symptoms; 14 of them were oophorectomized. The first group of patients received 4 mg of oestriol succinate per day or a placebo in a double-blind experiment. In the second part of the study oophorectomized women were given 8 mg of oestriol succinate per day or 16 mg/day divided into two doses. Serum total cholesterol, HDL-cholesterol and serum triglycerides were estimated before drug treatment and after drug administration for three and six months. Administration of 4-16 mg/day of oestriol succinate was without effect on serum total cholesterol. A significant increase of 25-30% in HDL-cholesterol was observed following administration of oestriol succinate (8 mg divided into two doses) with a rising tendency in total triglyceride value.

References

Apr 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·R PuukkaM Puukka
Jan 1, 1980·Acta Obstetricia Et Gynecologica Scandinavica·D E Englund, E D Johansson
Jan 1, 1965·Journal of Atherosclerosis Research·R W ROBINSON, R J LEBEAU

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Citations

Oct 21, 2004·The Cochrane Database of Systematic Reviews·A H MaclennanV Moore

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