Effect of .OH scavenging action by non-SH-containing angiotensin converting enzyme inhibitor imidaprilat using microdialysis

Journal of Physiology, Paris
T Obata, Y Yamanaka

Abstract

We examined the effect of non-SH-containing angiotensin converting enzyme (ACE) inhibitor imidaprilat on hydroxyl radical (.OH) generation using microdialysis. Salicylic acid in Ringer's solution containing sodium salicylate (0.5 n mol microL-1 min-1) was infused directly through a microdialysis probe to detect the generation of .OH as reflected by the formation of 2,3-dihydroxybenzoic acid (DHBA) in the myocardium of anesthetized rats. We compared the ability of two non-SH-containing ACE inhibitors (imidaprilat and enalaprilat) with an -SH-containing ACE inhibitor (captopril) to scavenge the .OH. When iron (II) was administered to animals pretreated with these three ACE inhibitors, a decrease in 2,3-DHBA of all three compounds was observed, as compared with the iron (II) only-treated group. All three ACE inhibitors were able to scavenge .OH generated by the action of iron (II). However, imidaprilat is a free radical scavenger more potent than enalaprilat. These results suggested that ACE inhibitors are probably not only related to the presence of the SH radical.

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Citations

Sep 28, 1998·Biochimica Et Biophysica Acta·H WuX Q Liu
Jun 5, 1998·Trends in Genetics : TIG·S M Rosenberg
Jun 15, 1999·Trends in Biochemical Sciences·F B Perler
May 13, 1999·Journal of Neurophysiology·A J SokoloffT C Cope

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