PMID: 3468521Jan 1, 1987Paper

Effect of OKY-046, a selective thromboxane inhibitor, on prostaglandin production and function of pregnant rat uteri and platelets

Prostaglandins, Leukotrienes, and Medicine
R B Ghodgaonkar, N H Dubin

Abstract

The effect of OKY-046 (ONO, Japan), a selective TX inhibitor, was studied for its effect on uterine and platelet activity. On day 21 of pregnancy, rats were injected with either 0, 1, or 5 mg/kg OKY-046 via the tail vein. One hour following injections, in vitro activity of uteri and platelets was assessed. A decrease (P less than .01) in uterine TXB2 production (measured by RIA) occurred with increasing OKY-046 dose (104 +/- 31 vs 44 +/- 6 vs 24 +/- 2 ng TXB2/g tissue/45 min). OKY-046 treatment had no effect on other prostanoids. Contractile activity was not affected by OKY-046. The amount of TXB2 produced in platelets from OKY-046 (5 mg/Kg) treated rats was 45.5% less than that from controls (P less than .001). Likewise, arachidonate-induced aggregation of platelets from OKY-046 treated rats was 46.1% less (P less than .05) than that of controls. In summary, in vivo administration of OKY-046 selectively reduced uterine TXB2 without altering other prostanoids, or affecting uterine contractions. In contrast, both platelet TXB2 production and platelet function (aggregation) was decreased.

References

Nov 1, 1977·Prostaglandins·K I Williams, I Downing
Jun 1, 1978·British Journal of Obstetrics and Gynaecology·M D MitchellA C Turnbull
Jan 1, 1983·Thrombosis Research. Supplement·M J Randall
Jan 1, 1983·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·H Kindahl, E Granström
Sep 1, 1980·Journal of Reproduction and Fertility·N L Poyser, F M Scott
Mar 1, 1982·Biology of Reproduction·N H DubinR B Ghodgaonkar

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