Effect of older donor age on risk for mortality after heart transplantation

The Annals of Thoracic Surgery
Dipin GuptaSatoshi Furukawa

Abstract

Despite the increasingly common use of donor hearts at least 50 years of age, controversy still remains regarding long-term outcome. Our goal was to determine if older donor age is associated with an increased risk of mortality and specifically if the use of donor hearts at least 50 years of age reduces survival. We retrospectively studied records of all primary heart transplants performed between January 1990 and July 2002. Fifty-six patients who had received donor hearts at least 50 years of age were compared with 611 recipients of donor hearts less than 50 years of age. Clinicopathologic parameters were analyzed for their effect on mortality using the Cox proportional hazard model with calculation of hazard ratios (HR). Cut-point analysis of donor age was used to determine which donor age is associated with the greatest risk of mortality after transplant. Recipients of donor hearts at least 50 years of age were older (58.5 years +/- 7.0 vs 53.2 +/- 11.6; mean +/- standard deviation [SD]; p < 0.0001), suffered more often from ischemic cardiomyopathy (69% vs 50%, p = 0.01), and experienced a longer waiting time (192.2 days +/- 301.0 vs 138.6 +/- 190.8, p < 0.0001). Donor hearts at least 50 years of age (age 54.1 +/- 3.5 years)...Continue Reading

References

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Citations

Apr 1, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Giuseppe BruschiLuigi Martinelli
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Arun K SinghalBruce I Goldman
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Jul 13, 2020·Clinical Transplantation·Andrea LechiancoleUgolino Livi
May 23, 2018·Interactive Cardiovascular and Thoracic Surgery·David PrietoManuel J Antunes
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Sep 2, 2018·Journal of Critical Care·Shengnan LiUNKNOWN Monitoring Organ Donors to Improve Transplantation Results (MOnIToR) Study Investigators
May 22, 2021·Journal of Cardiac Surgery·Paul C TangJonathan W Haft

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