Effect of olfactory impairment and white matter hyperintensities on cognition in Parkinson's disease

Parkinsonism & Related Disorders
Jee Hyun HamPhil Hyu Lee

Abstract

Although white matter hyperintensities (WMH) and olfactory dysfunction are independently associated with the cognitive impairments in Parkinson's disease (PD), the effects of simultaneous presence of these abnormalities remain unknown. Thus, we investigated the different effects of deep WMH and periventricular WMH on olfactory and cognitive performance and evaluated the additive effects of the concurrent presence of WMH and olfactory dysfunction on cognitive performance in PD. We enrolled 171 patients with non-demented PD whose WMH scores were assessed using a semi-quantitative visual rating system. The olfactory and cognitive performance was assessed using the Cross-Cultural Smell Identification (CCSI) test and the Seoul Neuropsychological Screening Battery. Additionally, the additive effects of concurrent WMH and olfactory dysfunction on cognitive performance were investigated using binary logistic regression. The deep WMH score exhibited a significant negative correlation with the CCSI score (p = 0.026) but the total WMH and periventricular WMH did not. A multiple regression analysis revealed that the total WMH (β = -0.109, p = 0.011) and deep WMH (β = -0.153, p = 0.020) severities had significant negative correlations with ...Continue Reading

References

Jul 26, 2002·Current Opinion in Neurobiology·Ivanka Savic
Dec 3, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R VatajaT Erkinjuntti
Oct 11, 2005·Brain Research. Brain Research Reviews·Jay A Gottfried, David H Zald
May 13, 2008·Biological Psychiatry·Ki Woong KimMartha E Payne
Oct 8, 2008·Neuroscience Letters·Nicolaas I BohnenRobert Y Moore
Apr 8, 2009·Neuroreport·Joana B PereiraEduard Tolosa
Apr 24, 2010·Brain : a Journal of Neurology·Nicolaas I BohnenKirk A Frey
Jun 18, 2010·Brain Research·Thomas BitterOrlando Guntinas-Lichius
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Naroa Ibarretxe-BilbaoEduardo Tolosa

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Citations

Jan 15, 2018·Journal of Alzheimer's Disease : JAD·Juliette HeinrichEmmanuelle Duron
Feb 7, 2017·Journal of the International Neuropsychological Society : JINS·Jacob D JonesDawn Bowers
Jun 18, 2020·Frontiers in Neurology·Bruce A Chase, Katerina Markopoulou
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna PierzchlińskaMonika Białecka
May 12, 2021·Journal of the Neurological Sciences·Asif ButtRichard Camicioli

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