PMID: 11903739Mar 21, 2002Paper

Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach

Journal of Gastroenterology and Hepatology
B KangA S Giraud

Abstract

Omeprazole is an inhibitor of the H+K+ ATPase of the gastric parietal cell, which is used clinically to suppress gastric acid secretion. It has also been found to inhibit gastric mucin production; however, its effects on the synthesis and secretion of the trefoil peptides, which are also expressed by mucus cells, and which play a key role in cytoprotection and epithelial repair, are unknown. Rats (n=8) were given either omeprazole (30 mg/kg per day; p.o.) or inert carrier for 1 week, and the effects on synthesis and peptide expression of the gastric trefoil peptides, TFF1/pS2 and TFF2/SP, were compared. As expected, omeprazole treatment abolished H+ ion production with a mean gastric juice pH of 7.2 compared with 2.4 for controls. The omeprazole group had elevated total protein levels of 35-fold and TFF1/pS2 peptide levels elevated fourfold, respectively, but not TFF2/SP peptide in gastric juice, suggesting that the increased pH reduced the viscosity of adherent mucus, thereby increasing gastric juice concentrations by dissolution of adherent TFF1/pS2 and increased secretion. Concomitant with increased TFF1/pS2 secretion was a fall in predominantly antral mucosal trefoil peptide concentrations. In contrast to trefoil secretory ...Continue Reading

References

Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·M KagoshimaH Shimada
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M C RioP Chambon
Nov 1, 1985·Digestive Diseases and Sciences·J A Steiner
Nov 1, 1985·Digestive Diseases and Sciences·A Allen, N J Carroll
Nov 1, 1983·The American Journal of Physiology·J H WiddicombeE Highland
Apr 1, 1996·Alimentary Pharmacology & Therapeutics·J G Penston, K R Mistry
Feb 1, 1996·Alimentary Pharmacology & Therapeutics·K YoshimuraC R Boland
Jun 26, 1998·Journal of Gastroenterology and Hepatology·G A CookA S Giraud
May 14, 1999·Gut·W M WongN A Wright

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Citations

Oct 13, 2006·Current Opinion in Gastroenterology·Sushovan Guha, Jonathan D Kaunitz
Feb 11, 2005·Current Opinion in Gastroenterology·Luke C Bi, Jonathan D Kaunitz
Nov 3, 2007·The Journal of Pharmacy and Pharmacology·Debashish BanerjeeSubrata Chattopadhyay
Jan 3, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hye J ChungMyung G Lee
Dec 20, 2016·Annual Review of Physiology·Eitaro AiharaMarshall H Montrose
Sep 16, 2005·Biopharmaceutics & Drug Disposition·Joo H LeeMyung G Lee
Jul 11, 2003·World Journal of Gastroenterology : WJG·Bao-Ping YuJie-Ping Yu

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